Jinan City People's Hospital

APOF regulates the malignancy and inflammatory response of hepatocellular carcinoma cells through PPAR signaling pathway

Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence. It is often diagnosed at an advanced stage, with intrahepatic or extrahepatic metastasis, and cannot be cured by radical surgery. In human HCC cell lines, Apolipoprotein F (APOF) gene promoter activity was s...

Biotin‐Engineered Phenothiazine Photosensitizer Boosts Type I Photodynamic Therapy via Singlet‐Excited‐State Electron Transfer

Comprehensive Summary Type II‐dominant photosensitizers often suffer from reduced photodynamic efficacy under tumor hypoxia. We report a biotin‐modified phenothiazine photosensitizer termed DHU‐Blue‐7, which converts type II methylene blue (MB)‐like photosensitization into a type...

EXPRESS: Diagnostic Accuracy of Noninvasive Translesional Pressure Ratio Based on Magnetic Resonance Imaging for Intracranial Atherosclerotic Stenosis: A Validation Study

The anatomic stenosis severity of intracranial atherosclerotic stenosis (ICAS) does not reliably reflect lesion-specific hemodynamic impairment, and invasive pressure-wire assessment is technically challenging in the cerebral circulation. This study aimed to develop and validate...

Perioperative esketamine and postoperative sleep quality: a systematic review and meta-analysis of randomized trials

Abstract Background Postoperative sleep disturbance (PSD) is common among surgical patients and adversely affects recovery. The benefits of perioperative esketamine on sleep remain incompletely defined. Methods Randomized controlled trials (RCTs) comparing ketamine or esketamine...