Jikei University School of Medicine

Piezo1–Src signaling rapidly disrupts brain endothelial barrier integrity

Abstract Background Blood-brain barrier integrity is essential for central nervous system homeostasis, yet the mechanisms underlying ultra-acute barrier dysfunction after abrupt hemodynamic changes remain incompletely understood. Piezo1 is a mechanosensitive Ca²⁺ channel expresse...

Association between hemoglobin A1c levels and coronary flow reserve in angina with nonobstructive coronary arteries: a retrospective observational study

Abstract Background Hemoglobin A1c (HbA1c) measures chronic glycemic levels, and its elevation is associated with vascular endothelial dysfunction and microcirculatory impairment, contributing to increased cardiovascular risk. In the assessment of angina with nonobstructive coron...

Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)

OBJECTIVE: The primary objective of the study was to evaluate the safety and effectiveness of olaparib maintenance therapy in Japanese patients with platinum-sensitive first-relapsed ovarian cancer. The secondary objective was to survey the treatment given after the olaparib main...

Association between awareness of government notification and ‘negative hepatitis virus test result card’ and implementation of hepatitis B and C screening in Japanese workplaces: a cross-sectional study

Abstract Background ‘Request for cooperation on measures against viral hepatitis in the workplace’ (the notification) was issued to provide hepatitis screening opportunities in workplaces. However, employees may take hepatitis tests multiple times because the results are not reco...

Serial ultrafine endoscopic assessment of fibrin deposition and neomembrane formation in peritoneal dialysis patients using low glucose degradation product fluid

Preservation of the peritoneum is essential for the safe continuation of peritoneal dialysis (PD). Although PD fluid with low glucose degradation products (low GDP) are widely used, objective macroscopic assessment of the peritoneum during ongoing PD remains limited. We therefore...