Jikei University School of Medicine

A case of renal hypouricemia type 1 associated with compound heterozygous URAT1/SLC22A12 variants A209V and F379L: clinical evidence for their pathogenic significance

Abstract Renal hypouricemia (RHUC) is an inherited renal tubular disorder characterized by low serum uric acid levels and excessive urinary uric acid excretion due to impaired urate reabsorption in proximal tubules. Type 1 RHUC (RHUC1) is caused by pathogenic variants in URAT1/SL...

Seasonal variation in day-to-day blood pressure variability: large-scale within-individual home blood pressure data

Abstract Day-to-day home blood pressure (BP) variability predicts cardiovascular and cognitive risk, but whether it shows seasonal variation within the same individual remains uncertain. We examined its seasonal patterns using repeated personal health record measurements. We anal...

Central visual field defect patterns and progression in glaucoma: a multicentre 10-year study

Background/aims To determine whether baseline central visual field defect (CVFD) distribution and archetypal 10–2 patterns are associated with subsequent central visual field (VF) progression in glaucoma. Methods This retrospective multicentre longitudinal cohort included 127 eye...

Surface Morphology Control and Amino Functionalization of Silicon Nanoparticles for Enhanced Antibody Immobilization

The large specific surface area of nanoparticles makes them an attractive platform for antibody immobilization in immunoassays, but the combined effects of their surface structuring and chemical functionalization on properties relevant to antibody immobilization have not yet been...

Diffuse midline glioma, H3 K27-altered, forming a suprasellar mass: A case report

Diffuse midline glioma, H3 K27-altered (DMG), is an extremely aggressive tumor that mainly arises in midline structures such as the thalamus, brainstem, and spinal cord in children and young adults. We report a rare adult case of DMG presenting as a suprasellar mass. A 56-year-ol...

Machine learning integrated explainable artificial intelligence in predicting toxicities of enfortumab vedotin in urothelial carcinoma: an exploratory study

Background Enfortumab vedotin (EV) therapy for advanced urothelial carcinoma is limited by adverse events (AEs). Early identification of high-risk patients is needed. This proof-of-concept study evaluated whether machine learning (ML) with explainable AI (SHAP) could predict EV t...

Impact of baseline renal function on the clinical outcomes and safety of adjuvant nivolumab in high-risk urothelial carcinoma: a multicenter retrospective real-world study

Abstract Background Adjuvant nivolumab prolongs disease-free survival (DFS) in patients with urothelial carcinoma (UC) after radical surgery; however, evidence in those with reduced baseline renal function is limited. We investigated the impact of baseline creatinine clearance (C...

Development of a prognostic model for elderly patients with metastatic clear cell renal cell carcinoma treated with first-line immuno-oncology combination therapy.

BACKGROUND: In the era of immuno-oncology (IO) combination therapy, prognostic tools for elderly patients with metastatic clear cell renal cell carcinoma (ccRCC) are lacking. This study aimed to identify prognostic factors in elderly patients and evaluate a novel risk model using...

Effect modification by baseline lactate in the association between time to assigned mean arterial pressure target and outcomes in older patients with septic shock: a post hoc analysis of the OPTPRESS trial

Time to target mean arterial pressure (TTT-MAP) may capture the temporal dimension of circulatory recovery in septic shock; however, its prognostic relevance needs clarification. This study aimed to investigate the impact of baseline lactate on the TTT-MAP-clinical outcome associ...

Outcomes of Curative‐Intent Endoscopic Resection Combined With Adjuvant Immune Checkpoint Inhibition for Resectable Sinonasal Mucosal Melanoma

ABSTRACT Background Evidence for adjuvant immune checkpoint inhibitor (ICI) therapy after curative‐intent resection of sinonasal mucosal melanoma (SNMM) is limited. Methods We retrospectively reviewed 11 patients with resectable N0M0 SNMM who underwent curative‐intent endoscopic...

Beyond cytoskeletal regulation: Rho-associated, coiled-coil-containing protein kinase 2 in kidney inflammation and fibrosis.

Chronic kidney disease (CKD), histologically defined by glomerulosclerosis, tubular atrophy, interstitial fibrosis, and capillary rarefaction, represents a profound challenge in cellular pathology. This review synthesizes recent advances to position Rho-associated, coiled-coil-co...

Piezo1–Src signaling rapidly disrupts brain endothelial barrier integrity

Abstract Background Blood-brain barrier integrity is essential for central nervous system homeostasis, yet the mechanisms underlying ultra-acute barrier dysfunction after abrupt hemodynamic changes remain incompletely understood. Piezo1 is a mechanosensitive Ca²⁺ channel expresse...

Association between hemoglobin A1c levels and coronary flow reserve in angina with nonobstructive coronary arteries: a retrospective observational study

Abstract Background Hemoglobin A1c (HbA1c) measures chronic glycemic levels, and its elevation is associated with vascular endothelial dysfunction and microcirculatory impairment, contributing to increased cardiovascular risk. In the assessment of angina with nonobstructive coron...

Association between awareness of government notification and ‘negative hepatitis virus test result card’ and implementation of hepatitis B and C screening in Japanese workplaces: a cross-sectional study

Abstract Background ‘Request for cooperation on measures against viral hepatitis in the workplace’ (the notification) was issued to provide hepatitis screening opportunities in workplaces. However, employees may take hepatitis tests multiple times because the results are not reco...

Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)

OBJECTIVE: The primary objective of the study was to evaluate the safety and effectiveness of olaparib maintenance therapy in Japanese patients with platinum-sensitive first-relapsed ovarian cancer. The secondary objective was to survey the treatment given after the olaparib main...

Serial ultrafine endoscopic assessment of fibrin deposition and neomembrane formation in peritoneal dialysis patients using low glucose degradation product fluid

Preservation of the peritoneum is essential for the safe continuation of peritoneal dialysis (PD). Although PD fluid with low glucose degradation products (low GDP) are widely used, objective macroscopic assessment of the peritoneum during ongoing PD remains limited. We therefore...