Jiangyin People's Hospital

An aging-informed multi-layer bioinformatics framework prioritizes GKN1 and PLAU/uPA-associated candidates in gastric cancer

Gastric cancer is molecularly heterogeneous. We used curated aging-gene annotation as a candidate-filtering prior, rather than as evidence of an aging mechanism, within an integrated bulk and single-cell bioinformatics framework. Differentially expressed genes in GSE29272 were in...

Hypoxia down-regulates METTL3 and WTAP activating Integrin/FAK signaling through m6A/IGF2BP3 dependent manners in TGFBI mRNA to promote pancreatic neuroendocrine neoplasms progression

Hypoxia along with N6-methyladenosine (m6A) plays crucial roles in human tumorigenesis by influencing nearly every aspect of RNA metabolism. Nevertheless, the physiological signals that regulate the equilibrium between methylation and demethylation under hypoxic conditions have y...

Edentulism and persistent activities of daily living disability: evidence from CHARLS with exploratory frailty mediation analyses

Edentulism has been linked to functional decline, but its association with persistent activities of daily living (ADL) disability remains unclear. This study examined the longitudinal association between edentulism and incident persistent ADL disability among middle-aged and olde...

A syringe-based nanoliquid biopsy platform integrating magnetic immunocapture and electrochemical assay for circulating tumor cells enumeration and molecular profiling in NSCLC patients

The number and phenotypic profile of circulating tumor cells (CTCs) have demonstrated their capability in cancer diagnosis and therapeutic efficacy assessment, while programmed death-ligand 1 (PD-L1) and major histocompatibility complex class Ⅱ (MHC-Ⅱ) emerge as core predictive b...

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clin...

From Intuitive Concern to Safety Action: A Qualitative Meta‐Synthesis of Nurses' Experiences of Recognising Patient Deterioration

ABSTRACT Aim To synthesise qualitative evidence on nurses' experiences of intuitively recognising patient deterioration. Background Nurses often report intuition, gut feeling or a sense that “something is not right” when patients deteriorate, yet how such concern is experienced,...