Jiangxi Provincial Academy of Medical Sciences

Physical activity and the prevalence of hypertension, hyperglycaemia, hyperlipidaemia, and their co-occurrence among middle-aged and older Chinese adults

Hypertension, hyperglycaemia, and hyperlipidaemia, collectively referred to as the “three highs” (3H), pose significant health risks globally. Physical activity (PA) is associated with cardiometabolic health; however, the associations of PA with individual and concurrent 3H condi...

Mitochondria–endoplasmic reticulum contacts as signaling platforms in chondrocyte homeostasis and osteoarthritis: from adaptive coupling to pathological amplification

Osteoarthritis (OA) is a progressive whole-joint disease in which cartilage degeneration remains a central pathological event. Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are prominent features of chondrocyte dysfunction, but how these processes are coordinate...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...