Jiangxi Maternal and Child Health Hospital

Self-reported pain, depressive symptoms and risk for cardiovascular diseases

Previous studies have found that both pain and depressive symptoms are deleteriously associated with cardiovascular diseases (CVD). The aim of current study was to investigate the joint association of pain and depressive symptoms with CVD risk. A total of 13,184 participants aged...

Consistent associations of BMI with ovarian response and pregnancy loss risk across PCOS, DOR, and tubal factor infertility: a complete-case mediation analysis of 8,923 IVF cycles

To investigate whether body mass index (BMI) affects in vitro fertilization (IVF) outcomes through consistent pathways across different infertility etiologies. A retrospective cohort study with mediation analysis. A reproductive medicine center in China. Of 11,524 eligible women...

Preparation and in vitro evaluation of amphotericin B-chondroitin sulfate polymer prodrug

Amphotericin B (AmB) remains the gold-standard antifungal agent, yet its clinical utility is severely limited by dose-dependent hemolytic and nephrotoxic side effects arising from its aggregation-prone nature and non-selective membrane binding. To address this challenge, we devel...

Clinical and Functional Analysis of a HABP4 Missense Variant in Chinese Han Women With Endometriosis

Background: Endometriosis (EM) is a complex gynecological disease whose underlying molecular mechanisms remain poorly understood. The discovery of cancer driver mutations in endometriotic lesions indicates that EM may share common molecular pathways with malignant tumors. Our pre...

A novel rare missense variant in PLCD1 is associated with recurrent spontaneous abortion and inhibits cell migration and invasion

Recurrent spontaneous abortion (RSA) is a common clinical complication during pregnancy and seriously affects the physical and mental health of women reproductive age. Its etiology and pathogenesis have not yet been fully clarified. In this study, we examined whether genetic vari...

Advances in the Diagnostic Evolution and Treatment of Atypical Lobular Endocervical Glandular Hyperplasia

Atypical lobular endocervical glandular hyperplasia (ALEGH) is a cervical precancerous lesion that develops independently of high-risk human papillomavirus (HPV) infection. It is regarded as a key intermediate stage in the progression from lobular endocervical glandular hyperplas...

Acupoint hot compress for labor-pain management: a randomized, parallel-group, controlled trial

Background Non-pharmacological pain management approaches, including acupoint hot compress, may provide valuable support for women dealing with pain during the latent stage of labor, but the evidence supporting this effect is limited. We investigated whether acupoint hot compress...

Establishing the role of ZBTB20 mutations in GnRH deficiency and impaired neurogenesis in the subventricular zone: a human cohort and animal model study

Background Congenital hypogonadotropic hypogonadism (CHH) arises from defective development or dysfunction of GnRH neurons. Olfactory bulb (OB) malformations frequently accompany CHH, a condition termed Kallmann syndrome (KS). Nevertheless, approximately 50% of CHH cases remain g...

Early prediction of preeclampsia among the advanced-age pregnant women: A retrospective multicenter study

Background Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity. Women of advanced maternal age (AMA, ≥ 35 years) constitute a rapidly expanding high-risk subpopulation in China. Existing first-trimester prediction models were derived in general obstetric...