Jiangsu Shengze Hospital

Cellular and spatial context of genetic convergence between insomnia liability and DTI ALPS perivascular diffusivity

Sleep has been linked to brain waste clearance and glymphatic/perivascular transport, yet whether insomnia shares genetic architecture with perivascular diffusivity remains unclear. Here we show that insomnia liability and diffusion tensor imaging measures along the perivascular...

Shared genetic architecture between gastric cancer and medication-use proxy phenotypes in East Asians highlights lipid-metabolic pathways and candidate cellular contexts

Gastric cancer (GC) remains a major cause of cancer-related mortality in East Asia, and metabolic and cardiovascular comorbidities are common in the same aging populations. However, the extent to which GC shares inherited genetic architecture with medication-use proxy phenotypes...