Jiangsu Province Hospital

Non-invasive alterations of extra-pancreatic nerves in pancreatic ductal adenocarcinoma: a comparative study

Abstract Background Alterations in pancreatic innervation are characteristic of pancreatic ductal adenocarcinoma (PDAC) and are closely associated with poor prognosis. However, existing research has primarily focused on perineural invasion into intra-pancreatic nerves, with less...

Microfocused ultrasound for facial and neck rejuvenation

Facial and neck skin laxity reflects age‑related changes in collagen fibers and deeper support structures. Growing patient demand for effective, non‑invasive tightening has driven interest in microfocused ultrasound (MFU) as a treatment modality. This study aims to evaluate the c...

IRP1 affects the long-term survival and function of iTregs by regulating ferroptosis and apoptosis

As an important classification of Tregs, iTregs play a critical role in inducing transplant immune tolerance. Iron metabolism is closely linked to iTreg function, and IRP1 serves as a central regulator of cellular iron homeostasis. However, the relationship between IRP1 and iTreg...

Multimodal Feedback-Enhanced Soft Hand Rehabilitation Robot: System Development and Preliminary Clinical Evaluation

Soft robotic systems have attracted increasing attention for hand rehabilitation because of their compliance, adaptability, and potential for comfortable human–robot interaction. However, the clinical translation of soft hand rehabilitation robots remains limited by insufficient...

AI-assisted telerehabilitation in early Parkinson’s disease: a multicenter, randomized, multi-arm comparative trial

Abstract This exploratory, multicenter, randomized, rater-blinded, multi-arm comparative trial aimed to evaluate the feasibility and exploratory clinical signals of an AI-facilitated telerehabilitation system across different intervention durations in early-stage Parkinson’s dise...

PTTG1 drives intestinal-type gastric cancer progression via G2/M checkpoint-mediated cell-cycle reprogramming

Intestinal-type gastric cancer (IGC) progresses through the Correa cascade, yet the molecular determinants of this transition remain insufficiently defined. Using single-cell RNA sequencing (scRNA-seq) on matched normal, intestinal metaplasia, and tumor tissues from five patients...

Development of a novel anoikis-related prognostic signature and validation of CD36 as a potential target for reversing 5-FU resistance in gastric cancer

Gastric cancer (GC) remains a leading cause of cancer-related mortality, with chemoresistance and metastasis being primary hurdles to effective treatment. Anoikis resistance is a critical survival mechanism enabling tumor dissemination; however, the cellular heterogeneity of anoi...

The Vaginal Microbiome Across the Continuum from HPV Infection to Cervical Cancer: A Narrative Review

Persistent high-risk human papillomavirus (HR-HPV) infection serves as the core prerequisite for cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. Accumulated translational evidence confirms that vaginal microecological homeostasis dominated by protective Lac...

METTL16 supports arginine biosynthesis and suppresses IL-1β production to attenuate allergic asthma

Allergic asthma is a common disease. We aimed to investigate the role of METTL16, an N6-methyladenosine (m6A) writer, in allergic asthma and epithelial homeostasis. Here we show that pulmonary METTL16 expression was decreased in patients with allergic asthma and in a murine model...

The stroke crisis in ageing societies: global trends, risk factors, and clinical validation

Stroke remains a major global public health challenge, particularly among the elderly population. This study aims to integrate MIMIC-IV clinical data with GBD 2021 data to analyse epidemiological trends and regional differences in stroke among people aged 70 and above, identify k...

Differential risk factors for intestinal ischemia and intestinal necrosis in acute irreducible groin hernia: development and internal validation of a two-stage risk stratification model

Acute irreducible groin hernia requires timely management, but the extent of bowel compromise and the likelihood of intestinal resection are often difficult to anticipate before surgery. Intestinal ischemia and irreversible necrosis represent distinct stages of bowel injury and m...

Mechanosensitive epitranscriptomics in cancer: linking tumor mechanics, RNA modification, and immune escape

Solid tumors are mechanically abnormal ecosystems in which extracellular matrix stiffening, compressive stress, interstitial pressure, and aberrant fluid flow reshape cancer, stromal, and immune cell behavior. In parallel, the cancer epitranscriptome has emerged as a dynamic regu...

Deep learning CT signature for predicting early liver metastases in pancreatic ductal adenocarcinoma

Accurately predicting the risk of early liver metastases (ELM) and identifying patients who are most likely to benefit from neoadjuvant therapy (NAT) are critical for pancreatic ductal adenocarcinoma (PDAC). Here, we develop a Mamba-based predictive model that integrates imaging...

Contribution of social determinants of health to racial disparities in metabolic dysfunction-associated steatotic liver disease among US adults

Abstract Background Racial and ethnic disparities in metabolic dysfunction-associated steatotic liver disease (MASLD) persist in the US population. We studied the impact of social determinants of health (SDOH) on the likelihood of developing MASLD and explored the contribution of...

Efficacy and Safety of DVDMS ‐Photodynamic Therapy for Dysphagia in Advanced Esophageal Cancer: A Phase II Clinical Trial

ABSTRACT Photodynamic therapy (PDT) is a localized treatment for esophageal stenosis and dysphagia in advanced cancer. This study evaluated the efficacy and safety of Cosiporfin sodium (DVDMS)‐mediated PDT for dysphagia in advanced esophageal cancer. In this Phase II trial, patie...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Characteristics associated with efficacy of hypoxia-inducible factor-prolyl hydroxylase inhibitors in renal anemia patients: a retrospective cohort study

Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) are novel drugs used to treat renal anemia patients.However, their efficacy in elevating hemoglobin levels varies among patients. We aimed to identify characteristics that could influence hemoglobin level in renal...

Association of systemic inflammatory indices NLR, SIRI, and MHR with carotid plaque in middle-aged and older adults: a retrospective cross-sectional study

To examine the associations of the neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with carotid plaque in middle-aged and older adults. This retrospective cross-sectional study inc...

Serum Lactate Dehydrogenase as a Potential Biomarker for Lateral Lymph Node Metastasis in Thyroid Cancer Patients After Total Thyroidectomy

Background: This study aimed to investigate the clinical significance of serum lactate dehydrogenase (LDH) as a potential biomarker in patients with thyroid cancer, particularly in association with lateral lymph node metastasis (MLN) after total thyroidectomy. Methods: A total of...

Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis

Backgroud Dental fluorosis is a prevalent endemic condition, yet its impact on the oral microbiota structure and resistance in children remains understudied.Objective To assess the microbial composition, diversity, functional pathways and co-occurrence patterns among urinary fluo...