Jiangsu Cancer Hospital

The CARM1–YIPF2 axis drives breast cancer progression and predicts poor prognosis

Objective To investigate the roles of CARM1 and its regulatory effect on YIPF2 in breast cancer progression. Methods Breast cancer cells were transfected with CARM1 siRNA to knock down CARM1 expression. Cell proliferation, apoptosis, migration, and invasion were assessed using Ed...

Multiregional single cell profiling reveals LGALS9 and CD44 mediated niche remodeling crosstalk in metastatic breast cancer

Abstract The transition from intraductal to invasive Breast cancer (BC) is driven by complex interactions within the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), a key stromal component, critically influence extracellular matrix remodeling, immune modulatio...

PTTG1 drives intestinal-type gastric cancer progression via G2/M checkpoint-mediated cell-cycle reprogramming

Intestinal-type gastric cancer (IGC) progresses through the Correa cascade, yet the molecular determinants of this transition remain insufficiently defined. Using single-cell RNA sequencing (scRNA-seq) on matched normal, intestinal metaplasia, and tumor tissues from five patients...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Distinct functional brain network alterations associated with 5-fluorouracil- and carboplatin-based chemotherapy regimens in CRC and NSCLC patients: a combined graph theory and group ICA study based on rs-fMRI

It is not yet clear whether there are differences in the impact of different chemotherapy regimens on brain function. Especially, the distinct brain network alterations between patients underwent different regimens are still unclear. This study aimed to explore regimen-associated...

INHBA expression enriched in α-SMA+ fibroblast-like cells is associated with COAD cell growth and 5-FU resistance with concomitant impairment of necroptosis-related signaling and antitumor immunity

Abstract Objectives Inhibin subunit beta A (INHBA), a member of the transforming growth factor-β (TGF-β) superfamily, has been implicated in tumor progression, but its cellular origin, functional roles, and underlying mechanisms in colon adenocarcinoma (COAD) remain largely unkno...

Germline Genomic and DNA Methylation Differences Between MGUS and Multiple Myeloma Among Patients of African Ancestry

Individuals of African ancestry (AA) have approximately twofold higher risk of multiple myeloma (MM) than individuals of European ancestry, yet the molecular determinants between monoclonal gammopathy of undetermined significance (MGUS) and MM remain poorly defined. We performed...

Research Progress in Metabolomics for Thyroid Cancer Diagnosis and Treatment.

Thyroid cancer （TC） is one of the most common endocrine malignancies with high incidence and heterogeneity.Its diagnosis mainly relies on ultrasound-guided fine-needle aspiration biopsy，while it still fails to give a definitive diagnosis in 15%-30% of lesions，leading to a lar...

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clin...

Metabolic Tumor Area: A Clinically Practical Prognostic Marker for Improved Risk Stratification in IPI Non‐High‐Risk DLBCL

ABSTRACT Metabolic tumor volume (TMTV) is a core 18 F‐FDG PET/CT prognostic marker for diffuse large B‐cell lymphoma (DLBCL), but its complex measurement and limited standardization restrict clinical utility. Metabolic tumor area (MTA) features simple operation and good reproduci...

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Transfer RNA-derived small RNAs (tsRNAs) are a novel class of small non-coding RNAs abundant in the bloodstream of cancer patients and involved in various physiological and pathological processes. However, the regulatory mechanisms and clinical significance of tsRNAs in colorecta...

Deciphering the landscape of human pathogenome in non-typhoidal Salmonella through multidimensional genomics

Non-typhoidal Salmonella (NTS) is a leading foodborne pathogen causing severe gastrointestinal and systemic infections, posing a significant global health burden. This study employed a genomic approach to investigate the functional and distribution characteristics of human pathog...

Development of a urine-based DNA methylation assay for early endometrial cancer detection: a multicenter diagnostic study

Endometrial cancer (EC) incidence is rising globally, yet diagnosis still depends on invasive procedures, which limit accessibility and delay early detection. A noninvasive, accurate, and accessible diagnostic assay is urgently needed to enable early EC detection. In this multice...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Effect of SEEKflex-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial

In elderly patients with preexisting cardiovascular and cerebrovascular diseases, laryngoscopy and tracheal intubation can provoke substantial hemodynamic disturbances, including hypertension and tachycardia, which may precipitate major cardiovascular or cerebrovascular events an...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

Breast cancer stemness drives tumor progression and therapy resistance, yet the underlying mechanisms remain poorly understood. In this study, we observed that RBM38 expression gradually decreases during breast cancer progression in MMTV - PyMT transgenic mice. Using a model with...