Jiading District Central Hospital

Evaluation of contrast-enhanced ultrasound-guided fine needle aspiration biopsy in thyroid nodule diagnosis: a study from two tertiary referral centers

PURPOSE: This study aimed to compare the final definitive diagnosis (FDD) rate and accuracy of contrast-enhanced ultrasound (CEUS)-guided fine-needle aspiration biopsy (FNAB) with conventional US-guided FNAB. METHODS: A two-center study was conducted to compare the diagnostic per...

AR/PARP Dual‐Targeting Bioactive Photosensitizer for Photo‐Immunotherapy of Prostate Cancer

Prostate cancer poses a severe threat to men's health worldwide, and conventional therapeutic modalities are associated with various limitations. Photodynamic therapy (PDT) offers distinctive advantages such as minimal invasiveness, mild side effects and repeatable treatment. How...

Anterior intervertebral osteotomy and fusion (AIOF): an IPUP-guided standardized extension of anterior cervical discectomy and fusion for multilevel cervical spondylotic myelopathy

Abstract Purpose To evaluate the clinical and radiographic outcomes of anterior intervertebral osteotomy and fusion (AIOF), guided by the inflection point of the uncinate process (IPUP), for the treatment of multilevel cervical spondylotic myelopathy (MCSM), and to compare these...

Estradiol-to-testosterone ratio versus testosterone in relation to thromboelastographic clot strength in men with type 2 diabetes: a secondary cross-sectional analysis

Testosterone deficiency is common in men with type 2 diabetes mellitus (T2DM) and has been associated with a procoagulant thromboelastography (TEG) profile. Whether the estradiol-to-testosterone ratio (E2/T) provides information beyond testosterone alone is uncertain. We performe...

Association of prenatal noise exposure with postpartum depressive symptoms and self-harm ideation

Environmental noise is a pervasive but understudied determinant of perinatal mental health. We investigated whether prenatal residential noise exposure was associated with postpartum depressive symptoms and clinically documented self-harm ideation, thereby extending evidence beyo...

Higher eGFRdiff is associated with increased risk of rapid kidney function decline in hypertensive individuals

Abstract Background Hypertensive nephropathy is the second contributing factor to end-stage renal disease, while the relationship between the difference between estimated glomerular filtration rates (eGFRdiff) and rapid kidney function decline (RKFD) in hypertensive patients rema...

Fc N-glycosylation heterogeneity of anti-MDA5 IgG is associated with interstitial lung disease severity via regulating FcγR/C1q signaling in MDA5 + dermatomyositis: a cross‑sectional study

<title>Abstract</title> Background To characterize Fc N-glycosylation patterns of disease-specific IgG (DSIgG) in anti-MDA5-positive dermatomyositis (MDA5 + DM) and evaluate their associations with interstitial lung disease (ILD) severity. Methods Eighty-four patients with MDA5 +...

Two-wave modified cardiometabolic index change patterns and incident edentulism in Chinese adults: a longitudinal study from CHARLS

Abstract Objectives Complete tooth loss is a late-stage oral health endpoint that may reflect cumulative oral, systemic, behavioral, and social risk processes. We examined whether two-wave patterns of the modified cardiometabolic index (MCMI) from 2011 to 2015 were associated wit...

MRgFUS-enabled nanogel platform for synergstic chemo-immunotherapy in glioblastoma

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor prognosis and limited responsiveness to temozolomide (TMZ)-based chemoradiotherapy. Treatment remains hindered by the blood-brain barrier (BBB), blood-brain tumor barrier (BBTB), acquired TMZ resistance, a...