Jewish General Hospital

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

The acceptability and feasibility of a patient-oriented music intervention (POMI) for use in the adult intensive care unit: a crossover pilot randomized controlled trial

Abstract Background Music is suggested as a complementary pain management intervention in the intensive care unit (ICU). However, evidence from interested parties on the acceptability and feasibility of music in the ICU is scarce. A patient-oriented music intervention (POMI) was...

Overcoming Intra-Articular Delivery Barriers in Cartilage Regeneration: Emerging Controlled-Release Strategies

Articular cartilage has a limited capacity for self-repair due to its avascular nature, dense extracellular matrix, and low cellularity. Current treatments for cartilage injury and osteoarthritis (OA) often provide temporary symptom relief but do not restore native tissue structu...

Trauma-Focused Therapy in Sexual and Gender Minority Individuals: A Scoping Review of Therapeutic Interventions Contributing to Accessibility and Outcomes

Rates of trauma exposure and post-traumatic stress disorder (PTSD) are much higher in sexual and gender minorities (SGMs). However, negative psychotherapy experiences are frequently reported in this population. There is limited existing literature on outcomes for SGMs in trauma-f...

What works in transdiagnostic adult psychiatric day treatment programs? A scoping review of common components contributing to improved mental health outcomes

Background Day Treatment Programs (DTPs) provide intensive, multidisciplinary, non-residential care for adults with acute or complex mental illness. Despite their long-standing role as recovery-oriented alternatives to inpatient admission, contemporary DTPs vary widely in structu...

Acceptability of My Ten: a physical activity intervention for family caregivers of people with advanced cancer

Abstract Background The caregiving experience can have a significant impact on family caregivers’ (caregivers) health and well-being, particularly those of patients with advanced cancer. Interventions to support caregivers through health-promoting strategies are needed. The physi...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

A SORT1-associated transcriptional signature links adipogenic plasticity, stemness and drug-resistance programs in 3D glioblastoma spheroids: dissection of ligand-dependent and ligand-independent arms

Three-dimensional (3D) culture of glioblastoma (GBM) cells recapitulates tumour-niche features lost in 2D monolayers, including stemness, metabolic plasticity and therapy resistance. By creating hydrophobic compartments that sequester lipophilic chemotherapeutics, increased adipo...

Indoxyl sulfate–associated vascular calcification is linked to mTORC1 and ER stress–integrated stress response signaling

Medial vascular calcification is a major cardiovascular complication of chronic kidney disease (CKD), with the uremic toxin indoxyl sulfate (IS) implicated in its pathogenesis. However, the molecular mechanisms by which IS promotes vascular calcification remain incompletely under...

Uncovering scleromyositis: no myth, just missed

Purpose of review Scleromyositis (SM), the muscle-specific manifestation of scleroderma, is increasingly recognized as a distinct myositis subset, yet it remains poorly captured by existing classification criteria and absent from therapeutic guidelines. This review provides recen...

ALY688 Protects Against Myocardial Ischemia‐Reperfusion Injury via Direct Effects and Rab8a‐Dependent Extracellular Vesicles

ABSTRACT Despite advances in percutaneous coronary intervention, ischemia‐reperfusion (IR) injury remains a major cause of morbidity and mortality. Adiponectin confers broad cardioprotective effects, motivating the development of adiponectin receptor agonists. Here, we investigat...

Plasma proteome reflects tissue damage and clinical manifestations in patients with inflammatory myopathies

OBJECTIVE: Tissue-specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating cle...

Osteosarcopenia Revisited: From Mechanisms to Management

Abstract Sarcopenia and osteoporosis are characterized by insufficient mass and function of skeletal muscle and bone, and often co-occur in older persons, a condition called osteosarcopenia. Loss of bone and skeletal muscle mass and function is driven by multiple risk factors tha...

Defining ‘psychedelic’

Humphry Osmond coined the term ‘psychedelic’ in 1956, conjoining ‘psyche’ for ‘soul’ and ‘delic’ for ‘to manifest’ or ‘illuminate’. Soul-illumination is a compound noun that describes a psychological state or process. Osmond intended for it to be a taxonomic noun—naming, not just...

Statistical methods, outcome structures, and research designs in hybrid type II effectiveness-implementation studies: protocol for a scoping review

<ns5:p>Background Hybrid type II effectiveness-implementation studies evaluate health intervention and implementation strategy effectiveness simultaneously. While the emphasis on each “side” varies within hybrid type II studies, the focus of this review is those that attempt a mo...

OvercomingElectrochemiluminescence Immunoassay (ECLIA)Limitations: Conformation-Independent Quantitation of a TherapeuticAntibody by LC–MS/MS

Abstract Monoclonal antibody therapies have transformed cancer treatment by enabling targeted intervention even in advanced disease stages. However, reliable monitoring of circulating therapeutic antibody levels is critical to ensuring efficacy and patient safety. This study inve...

Moving Equity into Practice: Evaluation of an Online Asynchronous Continuing Medical Education Program for Rheumatology Care

Objectives Persistent health inequities exist in the diagnosis, treatment, and outcomes of rheumatologic diseases among at-risk populations in Canada. Prior research identified barriers and facilitators experienced by at-risk populations in Canada when accessing rheumatology care...