Jessa Hospital

Disproportionate systolic blood pressure response relative to oxygen consumption identifies a high-risk haemodynamic phenotype in arterial hypertension

OBJECTIVES: Conventional definitions of hypertensive response to exercise (HRE) rely on absolute systolic blood pressure (SBP) thresholds, which do not account for the metabolic demand driving the pressor response and show inconsistent association with pathophysiology and prognos...

Prevalence and predictors of abnormal dyspnea during exercise in persons with type 2 diabetes: a cross-sectional study (PROTECTION trial)

Abstract Aim To determine the prevalence, characteristics, and predictors of abnormal exertional dyspnea in T2D during a maximal exercise test. Methods 97 adults with non-insulin-dependent T2D underwent spirometry, maximal upright cardiopulmonary exercise test with Borg 0–10 dysp...

Obesity, incretin-based therapies, and cardiovascular disease in women

Abstract Obesity in women is a growing and multifaceted public health challenge, driven by complex interactions among biological, hormonal, and psychosocial factors across the life course. From menarche to menopause, hormonal fluctuations influence fat distribution, energy balanc...

Antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation: an individual patient data network meta-analysis

BACKGROUND AND AIMS: Randomized trials demonstrated that in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) direct oral anticoagulants (DOAC) and a P2Y12 inhibitor reduce bleeding compared with vitamin K antagonist (VKA) plus dual antipl...