Jeju National University

Induction of Oviductal Carcinomas in B6C3F1 Mice Following Subchronic Co-Exposure to Ozone, 4-(N-Methyl-N-Nitrosamino)-1-(3-Pyridyl)-1-Butanone, and Dibutyl Phthalate

ABSTRACT The purpose of this study is the evaluation of the potential toxicity through subchronic exposure to 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibutyl phthalate (DBP) on ozone alone in B6C3F1 mice. Male and female B6C3F1 mice were exposed to 0.5 pp...

Mechanisms of Multi-Toxicant Oxidative Stress: Dysregulation of The NF-Κb/Iκb Axis By Ozone, 4-(N-Methyl-N-Nitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) and/or Dibutyl Phthalate (DBP)

ABSTRACT This study explores the NF-κB-mediated oxidative stress pathways in B6C3F1 mouse lungs and livers following 16- and 32-week exposures to ozone, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibutyl phthalate (DBP). EMSA and Western blot analyses reveal...