Jefferson Hospital for Neuroscience

Operant behavior is reliably impaired in a mouse model of Angelman syndrome

Angelman syndrome (AS) is a neurodevelopmental disorder characterized by cognitive impairment, absent speech, seizures, motor and sleep impairments, and caused by loss of function of the maternal copy of the UBE3A gene. Modeling the AS phenotype in preclinical models across behav...

Drosophila pyruvate kinase links metabolic state with circadian output via TARANIS and PDF

Abstract The circadian clock generates ∼24-hour rhythms that anticipate daily environmental changes. Circadian clock and glucose metabolism are tightly interconnected, and both are disrupted in aging and disease. To examine how glucose hypometabolism impacts circadian rhythm, we...