Japan Clinical Cancer Research Organization

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (m...

Long‐Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single‐Center Experience Involving Three Pediatric Patients

Severe congenital protein C (PC) deficiency is a rare inherited coagulation disorder that can be difficult to control with conventional medical treatment alone. We report a single-center case series of three pediatric patients with severe congenital PC deficiency who underwent li...

Institutional enrollment volume and clinical outcomes after surgery or chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma: a supplementary analysis of JCOG0502

Abstract Background Surgery and chemoradiotherapy (CRT) are standard options for clinical stage I esophageal squamous cell carcinoma (ESCC). JCOG0502, a multicenter, non-randomized, parallel-group comparison, demonstrated the non-inferiority of definitive CRT compared with surger...