Japan Agency for Medical Research and Development

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

ABSTRACT Histidine methylation is an evolutionarily conserved but poorly understood post‐translational modification. METTL18 is known to catalyze histidine N τ‐methylation in vitro, yet its physiological functions in mammals remain unclear. Here we show that mouse METTL18 possess...

Gut microbial and metabolic biomarkers for early-onset colorectal cancer

Early-onset colorectal cancer (EO-CRC) is a growing global health challenge with poorly understood etiology. While gut microbiota and metabolites are implicated in colorectal carcinogenesis, EO-CRC-associated signatures remain poorly characterized. This study presents the first l...