James S. McDonnell Foundation

An early shift from wetland-adjacent to upland farming in the Maya lowlands

Maize is a seed grain of global social and economic importance. It has a mutualistic relationship with humans that evolved in parallel with the decisions of farmers who intensified its production. This occurred in the context of climate change, human selection for improved variet...

Searching the Druggable Genome using Large Language Models

Summary: The druggable genome encompasses the genes that are known or predicted to interact with drugs. The Drug-Gene Interaction Database (DGIdb) provides an integrated resource for discovering and contextualizing these interactions, supporting a broad range of research and clin...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...