James Graham Brown Foundation

C3- and C5-deficient murine cells exhibit severe mitochondrial defects, indicating a pivotal, novel role of innate immunity in regulating hematopoiesis at the electron transfer chain level

We recently reported that the functional intracellular complement network, known as the complosome, is expressed in hematopoietic stem/progenitor cells (HSPCs). In our recent work, murine lineage-negative (Lin − ) bone marrow (BM) mononuclear cells (BMMNC) from C3-KO and C5 –/– m...