Jacobs (United States)

Chronic Minocycline Treatment during Early Adolescence Ameliorates the Prenatal Ethanol Exposure-Induced Increase in Addiction Risk and Microglial Morphological Activation

Abstract Prenatal ethanol exposure (PE) causes fetal alcohol spectrum disorders (FASD), which have a high prevalence in the United States. There are various cognitive and behavioral deficits in FASD, including increased addiction risk. The diagnosis of FASD is often delayed, and...

Hex -MASP for mapping the whole-tissue spatial proteome and the intrabrain distribution of monoclonal antibodies

Abstract Whole-tissue spatial proteomics level provides critical insights into region-specific biological regulations but remains challenging. Previously, we introduced the Micro-scaffold Assisted Spatial Proteomics (MASP) concept for whole-tissue mapping. However, this prototype...

Acquired hemophilia: insights from a multicenter real-life study in a middle-income country

Background Acquired hemophilia A (AHA) is a rare hemorrhagic disease with scarce published information from developing countries. Objectives The main objective was to describe the clinical manifestation and treatment, as well as laboratory characteristics of patients with AHA. Pa...