Jacksonville University

Ceftriaxone versus cefazolin plus gentamicin for antibiotic prophylaxis in Gustilo-Anderson type III open lower extremity fractures

OBJECTIVES: To compare fracture related infection (FRI) rates and outcomes between ceftriaxone (CTX) and cefazolin plus gentamicin (C+G) for antibiotic prophylaxis in Gustilo-Anderson (GA) type III open lower extremity fractures. METHODS: Design: Retrospective cohort study. SETTI...

Global burden of moyamoya syndrome in pediatric sickle cell disease and implications for the neurosurgical workforce: a systematic review

Abstract Objective The aims of the study were twofold: 1) quantify the global burden of pSCD|MMS, and 2) estimate the number of children who warrant specialist evaluation for possible surgical revascularization. Methods A systematic review was conducted following PRISMA guideline...

Evaluation of Systemic Pharmacotherapy in Bacterial Skin Infections: Adherence to Clinical Guidelines and Factors Associated with Treatment Outcomes

Background: Bacterial skin infections frequently require systemic antibiotic therapy, and adherence to clinical guidelines is important for optimizing treatment outcomes and antimicrobial stewardship. This study evaluated systemic pharmacotherapy for bacterial skin infections, gu...

Distinguishing Benign from Malignant Small Enhancing Breast Lesions Using Radiomics

Background/Objectives: Small enhancing lesions (often termed foci if lesion ≤ 5 mm) observed on breast magnetic resonance imaging (MRI) pose a persistent challenge. Their clinical relevance and the most effective management strategy remain unclear, often leading to unnecessary bi...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Artificial intelligence in electrocardiogram interpretation for cardiovascular diagnosis and risk prediction: a systematic review of evidence through May 2026

Abstract Background Artificial intelligence-enabled electrocardiogram (ECG) analysis has expanded across cardiovascular diagnosis, monitoring, and risk prediction, but published studies vary in methodology, validation, and clinical applicability. We systematically reviewed AI app...

Dural Puncture Epidural, Standard Epidural, and No Epidural: Comparative Effects on Labor Progression and Neonatal Outcomes

Objective: To compare non-epidural labor, standard epidural analgesia, and dural puncture epidural analgesia with respect to labor progression, obstetric outcomes, analgesia-related outcomes, and neonatal results. Methods: This single-center retrospective observational cohort stu...

Flumazenil Use in Benzodiazepine-Induced Delirium Reversal.

Delirium is a frequent and serious complication in critically ill patients, associated with increased mortality, prolonged hospitalization, and long-term cognitive impairment. The hypoactive subtype is particularly underrecognized, missed in up to 75% of cases, and carries worse...