Jacksonville College

Mutational profiles of hepatocellular carcinoma that arose in outbred mice after heavy-ion particle and γ-ray radiation

Cancer risk estimation from space radiation is challenged by the lack of relevant experimental and epidemiological data for human exposure to the high-charge, high-energy (HZE) ions that predominate in deep space environments. Genetically diverse outbred mice provide an effective...

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

Nicotinamide adenine dinucleotide (NAD) is a metabolic cofactor regulating energy metabolism, epigenetics, DNA repair, and signaling. Although NAD declines with vitamin B3 deficiency, disease, and aging, systemic consequences of chronic depletion remain unclear. Here, we characte...

Global Paid and Unpaid Productivity Losses Due to Gastrointestinal Cancer Mortality

OBJECTIVES: Gastrointestinal (GI) cancers contribute substantially to premature mortality, yet their full economic burden, including unpaid work, remains underquantified. We aimed to estimate global productivity losses attributable to GI cancer mortality, considering paid and unp...

Recognizing the limitations of CLIF-C ACLF in predicting outcomes following liver transplantation in acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is associated with a high short-term mortality. The Chronic Liver Failure-SOFA Consortium ACLF score (CLIF-C ACLF) predicts mortality in patients with ACLF, but its utility in predicting post-liver transplantation (LT) outcomes remains unclea...

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...

Prevalence of laryngopharyngeal reflux symptoms in divers

Introduction: Laryngopharyngeal symptoms (LPS) refer to aerodigestive complaints that may result from the retrograde flow of gastric contents into the upper aerodigestive tract. These symptoms may be under-recognised in populations exposed to mechanical or environmental stressors...

Prospective, randomized comparison of electromyographic neuromuscular responses from the adductor pollicis and abductor digiti minimi muscles during rocuronium-induced neuromuscular block

Background: Many clinicians monitor the abductor digiti minimi (ADM) muscle during surgery using electromyography (EMG) for ease and consistency of electrode placement, while practice guidelines recommend monitoring of responses at the adductor pollicis (AP) muscle. We compared t...

Patient Characteristics and Outcomes of Acute Pancreatitis Managed in a Hospital-at-Home Program: A Multicenter Retrospective Descriptive Study

Background/Objectives: Hospital-at-home (HaH) programs have emerged as an alternative model to brick-and-mortar (BaM) hospital management of acute conditions such as heart failure, pneumonia, pyelonephritis, and chronic obstructive pulmonary disease exacerbation among the others....

Feasibility of Laminar Functional Quantitative Susceptibility Mapping

ABSTRACT Purpose Layer fMRI is an increasingly utilized technique that provides insights into the laminar organization of brain activity. However, both blood‐oxygen‐level‐dependent (BOLD) fMRI and vascular space occupancy data (VASO) have certain limitations, such as bias towards...

Longitudinal Data from a Large, Multi-Target Stool DNA Colorectal Cancer Screening Program

Background & Aims: Multi-target stool DNA (mt-sDNA) is an established stool-based colorectal cancer screening test, yet long-term performance is not well-described. We evaluated follow-up colonoscopy rates & quality, neoplasia yield, and repeat-testing adherence over 10 years wit...

Older Age, STAG2 , and DNMT3A Mutations Predict Superior Posttransplant Survival in Newly Diagnosed Acute Myeloid Leukemia Treated With Venetoclax Plus Hypomethylating Agents

ABSTRACT Venetoclax (Ven) plus hypomethylating agents (HMA) is standard frontline therapy for newly diagnosed AML (ND‐AML) patients unfit for intensive chemotherapy and is also considered in younger, fit patients. However, consolidation with allogeneic stem cell transplant (ASCT)...

Clinical Outcomes of HIF-2α inhibition in Von Hippel-Lindau Disease: A Multicenter Real-World Study.

BACKGROUND AND OBJECTIVE: Management of von Hippel-Lindau (VHL) disease is challenging due to multisystem involvement and limited systemic treatment options. Belzutifan has shown promising efficacy in clinical trials; however, real-world data remain limited. We aimed to evaluate...

OntoCodex: a multi-agent biomedical ontology enrichment framework

Ontology enrichment is a critical but labor-intensive step in semantic knowledge representation. To address this challenge, we propose OntoCodex, a multi-agent framework that integrates large language models (LLMs), ontologies, curated knowledge sources, and standard vocabularies...