Institution
Jackson Laboratory
Recent research
- AI & ComputingOpen access
The target-engagement predictor, implemented within the InSilicoTrials cloud-based, AI-powered platform for model-informed drug discovery and development, enables early exploration of time-dependent pharmacological responses. Predictions can be generated using inputs ranging from...
- Health & MedicineOpen access
Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development
Abstract Disruptions in airway branching or alveolar differentiation during lung development can lead to severe respiratory deficiencies and neonatal death. The molecular mechanisms governing branching patterning and early alveolar formation remain elusive. Loss of Svep1 function...
- BiologyOpen access
Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...
- Health & MedicineOpen access
Not available.
- Health & Medicine
Most genetic variants associated with any complex trait are found in non-coding regions. Multiple studies have reported enrichment in single nucleotide polymorphisms (SNPs) found in specific sequences bound by CCCTCF-binding factor (CTCF). CTCF binds DNA to establish boundaries,...
- BiologyOpen access
Neurodegeneration and inflammation in a novel spinocerebellar ataxia 13 preclinical model
Abstract Neuroinflammation is a critical pathological feature underlying neurodegenerative diseases. Spinocerebellar ataxia 13 (SCA13) is a heterogeneous ataxia with several allelic variations of differing phenotypes. All are neurodegenerative and currently without effective trea...
- BiologyOpen access
Sharp cell type boundaries emerge from coordinated morphogen signaling
Classic models of the French flag problem depict sharp cell type boundaries emerging from threshold responses to morphogen gradients. How discrete cell type boundaries arise from morphogen signals that vary continuously across developing tissues remains incompletely understood. W...
- BiologyOpen access
Predicting genome-wide functional constraints with GPN-Star
Abstract Genomic language models have emerged as a powerful approach for learning genome-wide functional constraints directly from DNA sequences 1 . However, standard genomic language models adapted from natural language processing often require large model sizes and computationa...
- BiologyOpen access
Abstract Tobacco use is the leading preventable cause of death in the United States. Among the factors that contribute to tobacco initiation, use, and dependence, genetics may exert a strong influence. In mouse models, genetic differences between strains have been studied to inve...
- BiologyOpen access
Background The Lancet Oncology Commission on cancer genomics and precision oncology identified workforce capability, education, and training as major constraints to equitable implementation. As genomic and multi-omic technologies become integrated into cancer care, structured app...
- Health & MedicineOpen access
CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells
Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...