J. Craig Venter Institute

Leviathan: fast, memory-efficient, and scalable taxonomic and pathway profiling for (pan)genome-resolved metagenomics and metatranscriptomics

Functional profiling of meta-omics is essential for understanding microbial communities, yet support for custom genome-resolved reference databases is limited. We introduce Leviathan for integrated taxonomic and functional profiling at both genome and pangenome resolution. Leviat...

Structural variants contribute substantially to complex trait heritability

Despite accumulating evidence that structural variants (SVs) exert disproportionate functional effects, their genome-wide contribution to complex trait heritability has not yet been systematically quantified. Here, we introduce MiXeR-SV, a tool that integrates long-read-derived S...

ABCDscores: an R package for computing summary scores in the ABCD Study®

Abstract The ABCD Study® is the largest longitudinal research study of brain development and child health across the United States. The study generates a rich multimodal dataset, including file-based raw and derivative data and a curated tabulated dataset comprising data from a b...