Izmir Biomedicine and Genome Center

Evaluation of salivary Adseverin, DEFA-1 and sRANKL levels in periodontal health and disease: a cross-sectional study

This investigation aimed to evaluate salivary levels of adseverin (Ads), DEFA-1, and sRANKL in periodontal health, gingivitis, and periodontitis, and to explore their discriminatory potential across periodontal conditions. A total of 60 systemically healthy, nonsmoking individual...

Western diet induces MASLD and major transcriptional reprogramming in the liver-gut axis of early zebrafish larvae

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to western diet and sedentary lifestyle. While larval zebrafish are powerful discovery tools, standardized diets inducing early-stage MASLD are lacking. Here, we developed and early-stage zebrafis...

Pharmacokinetics of meloxicam following intramuscular, subcutaneous, and oral administration in white storks (Ciconia ciconia)

Abstract Background Meloxicam (MLX) is a preferential cyclooxygenase-2 inhibitor widely used in avian medicine as an anti-inflammatory agent. Despite marked interspecific variability in avian drug disposition, no pharmacokinetic data are available for MLX in the white stork ( Cic...

Contribution of One‐Electron Oxidation of Purine and Pyrimidine Bases to the Photo‐ and Radiation‐Induced Damage to Cellular DNA

One‐electron oxidants that include type I photosensitizers, biologically relevant carbonate anion radical generators, and high intensity UVC nanosecond lasers are able to ionize in aqueous solution purine and pyrimidine nucleobases. The survey is aimed at critically reviewing the...