Iwate Medical University

2026 revised CVIT clinical expert consensus on drug coated balloons for coronary artery disease

Abstract Drug-coated balloons (DCBs) are attracting attention as a therapeutic alternative to drug-eluting stents (DES) in percutaneous coronary interventions. DCB technology allows direct delivery of antiproliferative drugs to the vessel wall without implantation of a permanent...

Impact of adjuvant chemotherapy on renal impairment patients following radical nephroureterectomy in upper tract urothelial carcinoma: a multicenter retrospective study

Abstract To evaluate the impact of adjuvant platinum-based chemotherapy (AC) on oncological outcomes in high-risk upper tract urothelial carcinoma (UTUC) patients with postoperative renal impairment following radical nephroureterectomy (RNU). Among 1050 patients who underwent RNU...

Effect of embedded catheter implantation on postoperative kidney function: the influence of kidney function in embedded catheter implantation

Abstract Background After the induction of peritoneal dialysis (PD), there is a risk of catheter-related infections and catheter dysfunction. To prevent infection, a surgical approach known as embedded catheter implantation has been developed. An advantage of this technique is th...

Prognosis and risk factors by histologic type of malignant ovarian germ cell tumors in Japan: a JSOG gynecologic tumor registry-based study

Objective: This study evaluated prognosis and risk factors for overall survival (OS) in malignant ovarian germ cell tumors (MOGCTs) using data from the Japan Society of Obstetrics and Gynecology tumor registry.Methods: Data from 1,538 MOGCT patients (2004MOGCT patients ( -2019) )...

Dental age estimation and assessment of the 18-year threshold using the third molar maturity index and dental development stages in a Korean population

Third molar development is widely used for forensic age estimation and for classifying individuals as adults or minors based on the legal age threshold. This study aimed to evaluate the applicability of Cameriere’s third molar maturity index and three stage-based indicators, Demi...

Aspirin Omission at the Time of Primary Percutaneous Coronary Intervention in STEMI

BackgroundThe safety of omitting up-front treatment with aspirin during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. MethodsWe conducted a multicenter, open-label, randomized trial in Japan i...

Separating extracellular from intracellular fecal metabolites exposes cross-feeding architecture in the gut: exploring metabolite partitioning and ecological associations

The gut microbiota forms a complex ecosystem through metabolic interdependence (cross-feeding). However, conventional fecal metabolomics typically quantifies only total metabolite pools, making it difficult to distinguish extracellular-enriched metabolite pools from predominantly...

P1.104. Potential Survival Benefit of Longitudinal ctDNA-Guided Treatment Adaptation in Advanced Esophageal Cancer

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background We have developed a tumor-specific circulating tumor DNA (ctDNA) monitoring test using digital PCR, termed the OTS (off-the-shelf)-assay. While recent attention has focused on minimal residual disease de...

Does increased staging complexity influence expert agreement in dental age estimation?

Dental age estimation (DAE) is a well-established procedure in current practice, and it is frequently required in forensic and legal investigations. This study aimed to evaluate the intra- and inter-observer reliability of dental development staging among forensic practitioners u...

Current Status of Bowel Preparation for Colonoscopy in Japan: A Web‐Based Survey of Endoscopists (PRESS Survey)

ABSTRACT Objectives The increasing number of patients with colorectal cancer underscores the importance of colonoscopy. Adequate bowel preparation is essential to ensure the quality and safety of colonoscopic examinations; however, data on the current practices in Japan remain li...

Smartphone-measured heart rate variability and quality of life in patients with gynecological cancer: a multicenter prospective study

In this study, we aimed to investigate the association between heart rate variability (HRV) and quality of life (QoL) in patients with gynecological cancer and examine whether continuous HRV monitoring may help identify QoL deterioration. This multicenter, prospective, observatio...

Immune Absence as a Proposed Framework for Delayed Relapse After Curative-Intent Treatment in Human Papillomavirus-Associated Cervical Cancer

Delayed relapse after curative-intent treatment remains difficult to explain and predict in human papillomavirus (HPV)-associated cervical cancer, including after periods of sustained remission with undetectable circulating tumor DNA (ctDNA) or circulating HPV DNA. This limitatio...

Differential Models of Time-Variant Tumor Growth Trajectories with Sensitive, Persister, Resistant Cell Population in Lung Tumors During Tyrosine Kinase Inhibitor Therapy

Modeling the dynamics of three tumor cell populations, i.e., sensitive, persister, and resistant tumor cells, during molecularly targeted therapy with tyrosine kinase inhibitors (TKIs) would be valuable for adjusting treatment plans for patients with epidermal growth factor recep...