Institution
ITMO University
Recent research
- Biology
Therapeutic nucleic acid (TNA)‐based gene silencing strategies, such as antisense oligonucleotides (ASOs), have been explored for cancer treatment. However, no ASO‐based anticancer drugs are currently available, largely because of limited therapeutic efficacy. Conventional ASO‐ba...
- Engineering & TechnologyOpen access
ABSTRACT Colloidal perovskite nanocrystals (NCs) are a well‐proven platform for growing anisotropic structures. Nanowires (NWs) exhibiting a quantum confinement phenomenon and microwires (MWs), which enable lasing, are of particular interest for optoelectronic devices. Synthesis...
- Engineering & TechnologyOpen access
In this work, the load-dependent indentation response of as-built Inconel 718 produced by direct laser deposition was studied, followed by local mapping around a single surface-intersecting pore. A working load of 100 mN was selected because the indentation modulus approached a d...
- Engineering & Technology
Abstract Battery power loss, sluggish sensor response, and surface icing in low-temperature environments demand flexible and efficient thermal management materials. Here, we propose a flash-laser heating strategy to fabricate Sn single-atom anchored laser-induced graphene (Sn-SA@...
- Health & Medicine
Abstract Objective: Recurrent vulvovaginal candidiasis (RVVC) is currently considered an immunopathological process. Fungal virulence factors and host immune responses, such as NLRP3 inflammasome activation, are thought to play an important role in the development of hyperinflamm...
- BiologyOpen access
Ziziphus lotus (L.) Lam (wild jujube) leaves are traditionally used in Moroccan medicine to treat hypertension. The present study evaluated the aqueous extract of Z. lotus leaves (ZLAqExt) for its vasorelaxant effects, mechanisms of action, acute toxicity, antioxidant potential,...
- Engineering & TechnologyOpen access
Implicit and Explicit Techniques for Space Elevator Simulation
The obvious way to simulate space elevator tether-climber dynamics is to discretize the tether using a mass-spring model, insert the climber into one of the springs, and simulate using an explicit solver. However, this approach either diverges or has unphysical disturbances when...
- Engineering & TechnologyOpen access
Implicit and Explicit Techniques for Space Elevator Simulation
The obvious way to simulate space elevator tether-climber dynamics is to discretize the tether using a mass-spring model, insert the climber into one of the springs, and simulate using an explicit solver. However, this approach either diverges or has unphysical disturbances when...
- Materials & EnergyOpen access
The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project
Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...
- Health & MedicineOpen access
Plant metabolites are a promising source of new biopesticides, but their chemical diversity exceeds the capacity of experimental screening. Cannabis sativa is a particularly attractive crop for discovering such compounds, although its metabolome has not been systematically evalua...
- AI & ComputingOpen access
In silico methods generate numerous toxicity predictions for natural compounds, yet their mutual consistency and transferability to new structures are rarely verified, and the predictions are often taken at face value. Using furanocoumarins of the genus Heracleum as a model class...
- Materials & EnergyOpen access
An efficient approach to unsymmetrical 1,10-phenanthroline-2,9-dicarboxamides based on the bifunctional reactivity of 4-oxo-7-haloderivatives is reported. These substrates exhibit orthogonal reactivity, enabling selective nucleophilic aromatic substitution at the C7 position alon...
- AI & ComputingOpen access
Synthesis of functional unknown input observers for MIMO systems with arbitrary relative degree
This paper addresses the design of functional unknown input observers for multi-input multi-output linear time-invariant systems. In contrast to many existing approaches, the proposed method is applicable to systems with arbitrary relative degree, which significantly enlarges the...
- Physics & SpaceOpen access
Non-Hermitian trapping of Dirac exciton-polariton condensates in a perovskite metasurface
Massless Dirac particles avoid trapping because of their exceptional tunneling properties manifested in the so-called Klein paradox. This conclusion stems from the conservative treatment, but so far, it has not been extended to a non-Hermitian framework. Recently, driven-dissipat...
- Materials & EnergyOpen access
The analysis of structural similarity among protein active sites is fundamental to understanding functional relationships between proteins and plays a critical role in structure-based drug design. Detailed characterization of protein‒ligand binding site similarity requires not on...
- Health & MedicineOpen access
Geometric misalignment degrades industrial cone-beam computed tomography (CBCT), particularly when a dedicated calibration phantom cannot be deployed during object acquisition. This study presents a three-stage, scan-specific geometric refinement framework that searches a bounded...