Italian institute for Genomic Medicine

MicroRNAs as dynamic processors: from thresholding to temporal decoding

MicroRNAs are central regulators of gene expression. Traditionally viewed as static repressors of protein output, their regulatory role is increasingly recognized as inherently dynamic. In living systems, gene regulation unfolds far from equilibrium, where signals fluctuate over...

RNAmotifs 2.0: a framework for inferring multivalent RNA motifs and their candidate regulators of splicing

Alternative splicing expands proteomic diversity and is shaped by RNA‑binding proteins (RBPs) that bind to multivalent RNA motifs. Yet connecting cis-acting motifs to their candidate trans-acting protein remains difficult from sequence information alone. Here we present RNAmotifs...