Istituto Universitario di Studi Superiori di Pavia

Radiographic accuracy of implant positioning in unicompartmental knee arthroplasty, does an imageless robotic system make a difference?

Abstract Background Robotic-assisted technologies and evolving implant designs have been introduced in unicompartmental knee arthroplasty (UKA) to improve the accuracy and reproducibility of component positioning. However, the relative contribution of robotic assistance compared...

Haplotype-specific analyses in apple: insights from 'Golden Delicious'.

Apple is one of the major cultivated fruit crops in temperate regions. To better support breeding programs and facilitate the development of improved cultivars, we generated a new haplotype-resolved and phased version of the 'Golden Delicious' genome, one of the founders of many...

Learning-Based Methods and the Future of Numerical Ocean and Sea-Ice Modeling

The field of operational oceanography is undergoing a significant evolution with the increasing integration of artificial intelligence (AI) methods, which are complementing and, in some cases, redefining traditional numerical modeling approaches. This review explores how AI metho...

Altered expression of ZAP70 and lnc-FAHD2B-3 in colorectal polyps: an exploratory molecular study

Colorectal cancer (CRC) is a major global health concern that often develops from precursor lesions, particularly adenomatous colorectal polyps. However, the molecular alterations associated with early colorectal neoplasia remain incompletely understood. ZAP70, a signaling molecu...

Integrating Deep Neural Networks with Support Vector Machines for Gene Expression Classification

Gene expression classification remains a challenging task due to the high dimensionality and heterogeneity of available datasets. In this study, we present a comprehensive empirical analysis combining neural networks and Support Vector Machines (SVMs) for gene expression classifi...

A Framework for Quantifying Diverse Multi‐Hazard Interactions to Enhance Climate Resilience

ABSTRACT Multi‐hazard events generate impacts exceeding those of individual hazards but remain difficult to assess due to complex interactions. This study presents a generalized framework for analyzing four interaction types—multivariate, preconditioned and triggering, spatially,...

Volume Electron Microscopy of Cortical Organoids: Methods for Region Identification, Connectome Reconstruction, and Organelle Segmentation

Abstract Volume electron microscopy (vEM) has become a powerful tool for 3D ultrastructural analysis of neural circuits, yet its application to human brain organoids remains limited, particularly for connectomic studies. Here, we established a comprehensive and scalable workflow...

Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection

<title>Abstract</title> Intracellular pathogens are ideal candidates for modelling the pathophysiology of chronic infection, as they hide within host cells and avoid conventional immune clearance through a controlled reshaping of cellular fate. This study unveils how the emerging...

Long-Term Assessment of UHI and SUHI in Modena: Integrating Landsat Land Surface Temperature and Meteorological Observations

The urban heat island (UHI) refers to higher air temperatures (Tair) in urban areas than in surrounding rural environments, while the surface urban heat island (SUHI) describes analogous differences in land surface temperature (LST). This study presents a long-term assessment of...