Istituto Pasteur

Residue-Level Energetic Analysis of Transient Misfolding in the Whirlin PDZ Tandem Reveals a Possible Connection to an AlphaFold-Predicted Alternative Topology

Multidomain proteins may populate transient misfolded states that compete with productive folding, but the molecular determinants of these intermediates remain poorly understood. Using the tandem PDZ domains of the scaffolding protein whirlin, in which a misfolded intermediate ac...

Telomeres in mitosis: organization and dynamics

Telomeres are specialized chromosomal structures that protect chromosome ends and maintain genome stability. Their organization depends on telomeric DNA repeats, the shelterin complex, accessory factors, and telomerase. While telomere structure and maintenance have been character...

MolecularStriptease of a Thiadiazolopyrimidine HitYields a Streamlined, Artifact-Free NADPH Mimic for NOX Inhibition

Abstract The convergence of oxidative stress and inflammation drives neurodegeneration and cancer, positioning NADPH oxidases (NOXs) as critical therapeutic targets. Starting from the polyfunctional thiadiazolopyrimidine hit 1, we systematically truncated its peripheral arms to m...

The Role of Direct-Acting Antivirals (DAAs) in Hepatitis C Virus-Associated Lymphoproliferative Disorders

Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis, affecting approximately 50 million people worldwide. An estimated 15–30% of individuals with chronic HCV infection progress to cirrhosis, which may subsequently develop into hepatocellular carcinoma. Beyond...