Istituto Neurologico Mediterraneo

Reliability and construct validity of the Italian EQ-5D-5 L in Parkinson’s disease: a cross-sectional study

Abstract Background Parkinson’s disease (PD) substantially affects health-related quality of life (HRQoL). The EQ-5D-5 L is a preference-based patient-reported outcome measure that supports cross-condition comparison and health-economic evaluation, but its measurement properties...

Stage-dependent performance and molecular subtype-specific relapse patterns on same-session [18F]FDG PET/contrast-enhanced CT in breast cancer

PURPOSE: To evaluate stage-dependent performance of same-session [18F]FDG PET/contrast-enhanced CT (PET/ceCT) for initial breast cancer staging and PET/ceCT-detected relapse patterns during follow-up. METHODS: This retrospective single-centre study included a primary staging coho...

Thalamocortical connectivity and nucleus-specific thalamic dysfunction in temporal lobe epilepsy: an integrative review

Temporal lobe epilepsy (TLE) is increasingly recognized as a distributed network disorder extending beyond mesial temporal structures. Among the brain regions implicated in epileptic network organization, the thalamus has emerged as a key hub due to its extensive structural and f...