Institution
Istituto Neurologico Mediterraneo
Recent research
- Health & MedicineOpen access
Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort o...
- Health & Medicine
OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy typically diagnosed in childhood. The 2022 International League Against Epilepsy (ILAE) criteria provide a diagnostic framework built on pediatric data, but their applicability in adulthood i...
- Health & MedicineOpen access
Multiple sclerosis (MS) is a chronic and progressively disabling neurological disease associated with a substantial clinical and socioeconomic burden. The introduction of an increasing number of new innovative therapies has further intensified concerns regarding the long-term sus...
- BiologyOpen access
Neuroinflammation is increasingly recognized as a biologically relevant component of neurodegenerative disease, yet its in vivo imaging remains difficult to interpret. This narrative update synthesizes original imaging studies published between January 1, 2020, and May 17, 2026,...
- BiologyOpen access
High-fat diet promotes T cell–mediated synaptic dysfunction in multiple sclerosis
Early glutamatergic synaptopathy contributes to disease progression in multiple sclerosis (MS), leading to excitotoxic synaptic damage. Although high-fat diet (HFD)–associated peripheral inflammation has been linked to central nervous system dysfunction, how metabolic and immune...
- Health & MedicineOpen access
DARE to wear: digital health promotion and disease prevention using wearable devices
Global healthcare systems are under increasing strain to ensure long-term sustainability, necessitating a transition towards proactive, preventive healthcare strategies. Wearable sensor technologies are uniquely positioned to facilitate this paradigm shift by allowing continuous...
- Health & MedicineOpen access
ABSTRACT Introduction The optimal duration of implantable loop recorder (ILR) monitoring remains uncertain and may differ according to the indication for implantation. We evaluated whether the time‐dependent diagnostic yield and clinical relevance of ILR‐detected arrhythmias diff...
- Society & Economics
Knowing enough: On the limits of knowing the patient in epilepsy care
This contribution is theoretical in nature and does not involve the generation or analysis of new data.
- BiologyOpen access
β2-containing nicotinic acetylcholine receptors (nAChRs) and dopamine D 2 receptors (D 2 Rs) cooperate to shape striatal dopamine (DA) output, yet the mechanisms by which nicotinic-dopaminergic crosstalk influences D 2 -like autoreceptor-mediated inhibition of DA release remain u...
- Health & MedicineOpen access
Abstract Background Parkinson’s disease (PD) substantially affects health-related quality of life (HRQoL). The EQ-5D-5 L is a preference-based patient-reported outcome measure that supports cross-condition comparison and health-economic evaluation, but its measurement properties...
- Health & MedicineOpen access
PURPOSE: To evaluate stage-dependent performance of same-session [18F]FDG PET/contrast-enhanced CT (PET/ceCT) for initial breast cancer staging and PET/ceCT-detected relapse patterns during follow-up. METHODS: This retrospective single-centre study included a primary staging coho...
- Health & MedicineOpen access
Temporal lobe epilepsy (TLE) is increasingly recognized as a distributed network disorder extending beyond mesial temporal structures. Among the brain regions implicated in epileptic network organization, the thalamus has emerged as a key hub due to its extensive structural and f...