Institution
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
Recent research
- Health & Medicine
Therapeutic Drug Monitoring of Antifungal Agents: Toward Harmonization of Therapeutic Ranges
Background: Invasive fungal infections are associated with high morbidity and mortality, particularly among immunocompromised and critically ill patients. Antifungal therapy is complicated by substantial pharmacokinetic variability, drug–drug interactions, and narrow therapeutic...
- Health & MedicineOpen access
Extrapulmonary tuberculosis: a 7-year retrospective study at a tertiary referral hospital in Rome
Extrapulmonary tuberculosis is increasingly reported in low-incidence settings, but its clinical spectrum, microbiological profile, and relationship with concurrent pulmonary tuberculosis remain incompletely defined. We aimed to characterize its epidemiology, clinical presentatio...
- BiologyOpen access
Background/Objectives: Multidrug-resistant (MDR) Pseudomonas aeruginosa pneumonia and bloodstream infections (BSI) remain challenging because of their severity, limited therapeutic options, and high mortality, despite the availability of novel β-lactam-based agents. We aimed to d...
- BiologyOpen access
New beta-lactam/beta-lactamase inhibitor combinations (BL/BLICs) are licensed for Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) infections. However, data regarding their efficacy against bacterial biofilms and the potential of synergistic comb...
- BiologyOpen access
Background/Objectives: The epidemiology of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) in Europe is evolving towards an increasing contribution of metallo-β-lactamases (MBLs). In particular, co-production of New Delhi metallo-β-lactamase (NDM) and OXA-48-like carbapenemase...