Institution
Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics And Applications
ITfacility
Recent research
- Health & MedicineOpen access
New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescence
Abstract p53 is, without a doubt, one of the most powerful genes in our genome, as it makes growth vs arrest, repair vs replacement, catabolism vs anabolism, life vs death decisions in the cell. An alteration or malfunction in p53 may lead to cancer, degeneration or premature age...
- Engineering & TechnologyOpen access
Abstract Determining the 3D structure of proteins is a long-standing challenge in the life sciences and is of paramount importance for understanding fundamental biological processes and advancing pharmaceutical development. Experimental techniques such as X-ray diffraction, nucle...