Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

Evidence to guide the treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with...

Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection

<title>Abstract</title> Intracellular pathogens are ideal candidates for modelling the pathophysiology of chronic infection, as they hide within host cells and avoid conventional immune clearance through a controlled reshaping of cellular fate. This study unveils how the emerging...

Sigh ventilation versus conventional protective ventilation in cardiac surgery: a proof-of-concept randomized controlled trial

Lung protective ventilation is crucial for preventing ventilator-induced lung injury in cardiac surgery. The protective role of a low tidal volume (V T ) has been established, whereas the added protection afforded by lung recruitment remains uncertain. We investigated whether sig...

Focal Therapy for Prostate Cancer

This retrospective study uses data from the National Cancer Database to examine patterns and temporal trends in use of focal therapy for prostate cancer in US cancer centers; characterize inappropriate use in low-, high-, or very–high-risk disease; and describe intermediate-risk...

Non-Invasive Prenatal Testing in Donor-Oocyte Pregnancies: Biological Determinants, Algorithmic Limitations and Clinical Implications

Non-invasive prenatal testing (NIPT) based on circulating cell-free DNA (cfDNA) has transformed prenatal screening for common aneuploidies, but its interpretation is less straightforward in pregnancies conceived with donor oocytes. In this setting, fetal chromosomal risk is large...

Visceral-to-subcutaneous fat ratio is a time-stable predictor of survival and toxicity in advanced hepatocellular carcinoma

Abstract Purpose Nutritional status significantly impacts the prognosis of patients with hepatocellular carcinoma (HCC). Computed tomography (CT) has become a key tool for assessing body composition (BC), with abnormal patterns increasingly linked to reduced survival. However, BC...

Iron oral supplementation in anemic patients undergoing orthopedic prosthetic surgery: a randomised trial comparing short_term and prolonged administration regimen

Preoperative anaemia in patients undergoing major elective orthopaedic surgery is a relatively frequent condition and is associated with perioperative transfusions. The aim of the present study was to investigate the efficacy of liposomal iron, folic acid, and vitamins in reducin...