Istituto di Nanotecnologia

Sensing‐Integrated Patient‐Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies, due to late diagnosis, poor therapeutic response, and high inter‐ and intra‐patient heterogeneity. Metabolic alterations, particularly extracellular acidification, critically impair drug respons...