Istituto Clinico Sant'Ambrogio

The Proteomic Profiling of a Platelet-Enriched Fraction Identifies an Inflammatory and Immune-Related Signature Associated with Non-Response to Treatment with Plasma Rich in Growth Factors in Knee Osteoarthritis

Background: The use of plasma rich in growth factors (PRGF) is a promising regenerative treatment for knee osteoarthritis (OA), but clinical response is heterogeneous. This study aimed to identify molecular features and explore clinical factors associated with PRGF non-response a...

Phytate and L-methionine for preventing recurrence of infection renal stones

BACKGROUND: Urine acidification and inhibition of crystallization are strategies that can be employed to prevent recurrent infection stones and calcium phosphate stones. METHODS: A series of cases demonstrating the beneficial effects of treatment with phytate and L-methionine in...

Exploring the potential of cluster analysis in identifying disease phenotypes in CPPD: Moving from intuition to insight

BACKGROUND: Calcium pyrophosphate deposition (CPPD) disease is a heterogeneous condition and is frequently misdiagnosed due to the different clinical presentations and variable disease progression. Aim of this study is to identify clinical phenotypes of CPPD disease by integratin...

Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Background: Facioscapulohumeral muscular dystrophy (FSHD) is a progressive and heterogeneous disorder lacking reliable circulating biomarkers for disease monitoring and therapeutic response. We hypothesized that metabolic dysregulation, lipotoxicity, and endoplasmic reticulum (ER...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Impact of postoperative pulmonary complications on survival after gastrectomy for cancer: individual patient data meta-analysis

Abstract Background Pulmonary complications (PC) may occur in up to 6.8% of patients after gastrectomy. Although PC are associated with prolonged hospital stay and increased overall healthcare costs, their impact on long-term survival remains controversial. This study aimed to an...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Assistive technologies (lumbar supports and other devices) for treating chronic low back pain

RATIONALE: Low back pain (LBP) is a major global health problem. It is the most common cause of activity limitation amongst individuals younger than 45 years, and one of the most frequent reasons for visits to a doctor. The 2019 Global Burden of Disease study named LBP as the lea...

When the Law Changes Therapy: Interrupted Time-Series Analysis of the Regulatory Impact on Intravenous Analgesic Consumption in 2 Italian Orthopaedic Hospitals (2021-2024)

Objectives: Tramadol is a centrally acting weak opioid widely used for moderate postoperative pain in orthopaedic surgery, so its regulatory status is directly relevant to hospital pharmacists. In November 2022 the Italian Ministry of Health reclassified tramadol as a controlled...

Food Supplements in Osteoarthritis: A Practical Framework for Discussing Evidence with Patients

The treatment of osteoarthritis (OA), a leading cause of disability worldwide, is increasingly integrating nutritional strategies that appear to offer the opportunity to significantly improve the quality of care. Patients are also aware of this and often seek clarification and ad...

Iron oral supplementation in anemic patients undergoing orthopedic prosthetic surgery: a randomised trial comparing short_term and prolonged administration regimen

Preoperative anaemia in patients undergoing major elective orthopaedic surgery is a relatively frequent condition and is associated with perioperative transfusions. The aim of the present study was to investigate the efficacy of liposomal iron, folic acid, and vitamins in reducin...

Comparisons of Novel Risk Stratification Models to the Current cT1a/b Staging in Incidental Prostate Cancer

OBJECTIVE: Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (< 5% vs. > 5%) in the resected tissue. We tested for other models that could improve cancer-specific survival (CSS) predictions. METHODS: Incide...