Istituti Clinici Scientifici Maugeri

Emerging therapeutic strategies and clinical trials in severe asthma management: current evidence and future directions

Introduction Biologic therapies have transformed the management of severe asthma, particularly in type 2-high disease, but important unmet needs remain. Incomplete responses, uncertainty in treatment positioning, and the lack of effective options for non-type 2 or mixed inflammat...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

The lived experience of trans persons: a bottom-up review co-written by experts by experience and academics.

We present here the first bottom-up review of the lived experience of trans persons, co-written by experts by experience and academics. We sourced the medical and non-medical literature, focusing on first-person narratives, and critically extracted experiential themes, which were...

Multimodal Neurorehabilitation Including Auditory EEG Neurofeedback: A Proof of Concept Tested After Resection of a Giant Olfactory Groove Meningioma

Background/Objectives: Patients undergoing resection of large olfactory groove meningiomas may present with persistent cognitive, behavioral, motor, and functional impairments. Evidence regarding EEG neurofeedback as part of postoperative neurorehabilitation remains preliminary....

Awakening the Vagus: Transcutaneous Auricular Vagus Nerve Stimulation—A Narrative Review

Disorders of consciousness (DoC), including unresponsive wakefulness syndrome/vegetative state (UWS/VS) and minimally conscious state (MCS), remain a major challenge in clinical neurology. Therapeutic options are limited, and prognosis is often uncertain. Transcutaneous stimulati...

Measurement Invariance of the Brief State Rumination Inventory Across Administration Methods, National Samples, and Sex

State rumination is a temporary activation of repetitive, negative, self-focused thinking in response to specific situational triggers or mood states. We present the results of two studies that examined the psychometric properties and measurement invariance of the Italian version...

Association of plasma growth differentiation factor-15 with the frailty phenotype – Evidence from the COGFRAIL study

Background Growth differentiation factor-15 (GDF-15) has been consistently associated with physical frailty. However, it remains unclear whether GDF-15 further discriminates adverse outcomes among older adults who are already physically and cognitively impaired. Objectives To eva...

Ultrasound-guided thermal ablation in patients affected by Graves’ disease: a systematic review and meta-analysis

Abstract Introduction Ultrasound-guided thermal ablation (U-GTA) techniques, including radiofrequency ablation (RFA) and microwave ablation (MWA), have recently been proposed as minimally invasive alternatives to surgery or radioiodine (RAI) therapy for patients with Graves’ dise...