İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi

Retinal Microvascular and Peripapillary Profiles in Mild Autonomous Cortisol Secretion Versus Nonfunctioning Adrenal Adenomas

Background/Objectives: Mild autonomous cortisol secretion (MACS) is associated with increased cardiometabolic morbidity, but its relationship with the retinal microcirculation is unknown. We compared retinal and peripapillary microvascular parameters between MACS and nonfunctioni...

Comparison of patient preference for and interpretability of video-based pain-expression scenarios and the numerical rating scale for postoperative pain assessment: a prospective observational study

Background: Postoperative pain assessment relies primarily on numeric self-report tools, such as the numerical rating scale (NRS); these tools require abstract numerical cognition and may be challenging for some patients in the immediate postoperative period. Thus, in this prospe...

Hierarchical diffusion-guided consistency learning framework for knee anterior cruciate ligament classification

Anterior cruciate ligament (ACL) classification in knee magnetic resonance imaging (MRI) is challenging due to diagnostic evidence being dispersed across multiple slices and anatomical supervision often being sparse. We propose a three-stage hierarchical diffusion-guided consiste...

Automated measurement of calcaneal inclination angle via partial semantic segmentation using U-Net

PURPOSE: To develop and validate an interpretable deep learning pipeline for the automated measurement of the calcaneal inclination angle (CIA) on lateral weight-bearing foot radiographs using partial semantic segmentation. METHODS: This retrospective single-center study included...

Composite Uric Acid Index for Prediction of Significant Coronary Stenosis on Computed Tomography Angiography

OBJECTIVE: A recently proposed uric acid index combining fasting glucose, triglycerides, and uric acid has shown promise in cardiovascular risk stratification. It was assessed whether the index could predict significant coronary artery stenosis (≥50%) on coronary computed tomogra...

Clinical Outcomes in Initial Hirudotherapy versus Standard Treatment in Idiopathic Granulomatous Mastitis: A Comparative Cohort Study

Objective: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease characterized by a high risk of recurrence and fistula formation. Spontaneous remission has been reported in up to 50% of cases, particularly in mild forms, within 6-24 months without interventio...

The Frontal QRS-T Angle and Cardiovascular Disease: A Narrative Review of Electrophysiological Basis, Measurement, and Clinical Utility

The QRS-T angle quantifies the divergence between the vectors of ventricular depolarization and repolarization and is regarded as a surrogate for global heterogeneity of ventricular repolarization. Its frontal-plane variant, calculated as the absolute difference between the autom...

Effect of Tamsulosin on Nocturnal Blood Pressure Load and Dipping Status: A Prospective Ambulatory Blood Pressure Monitoring Study

Background: Alpha-1 adrenergic receptor antagonists are widely used in the management of benign prostatic hyperplasia (BPH) . Their effects on blood pressure (BP) patterns remain incompletely characterized. This study aimed to prospectively evaluate the impact of tamsulosin on am...

Changing clinical presentation of pediatric celiac disease over time

Celiac disease (CD), often associated with malabsorption, presents with a wide spectrum of gastrointestinal and extra-intestinal manifestations. It was aimed to investigate changes in the clinical presentation of CD in children over a 16-year period and to assess whether clinical...

Cohort-level discrepancy between observed and model-based pedicle screw loosening risk: an exploratory aggregate-data evaluation of the explanatory gap index

Published pedicle screw loosening (PSL) cohorts differ substantially in observed event rates, predictor measurement, surgical context, and outcome ascertainment. We evaluated whether an aggregate discrepancy index can describe how far an observed cohort result lies from a common...

Perimenstrual repetitive greater occipital nerve blockade for menstrual migraine: a randomized, double-blind, placebo-controlled trial

Abstract Background The main purpose of this study is to demonstrate the decrease in headache severity, pain duration and the number of painful days in a month after repetitive GON blockade applied with local anesthetic in menstrual migraine patients compared to the placebo group...

Integrated Prognostic Stratification After Perioperative FLOT in Gastric and Gastroesophageal Junction Adenocarcinoma: A Multicenter Real-World Study

Background/Objectives: Outcomes after perioperative FLOT for gastric and gastroesophageal junction adenocarcinoma remain variable, even among patients treated with curative intent. Although postoperative pathological findings are central to risk assessment, they do not fully capt...