İstanbul Başakşehir Çam ve Sakura Şehir Hastanesi

From Anatomy to Biology: Tumor Location has Limited Independent Value in Predicting Pathological Complete Response After Neoadjuvant Chemoradiotherapy

Background Neoadjuvant therapy is the standard treatment for locally advanced rectal cancer; however, treatment response remains heterogeneous, and research has increasingly shifted from isolated anatomical predictors toward biologically integrated response assessment. This study...

Comparison of patient preference for and interpretability of video-based pain-expression scenarios and the numerical rating scale for postoperative pain assessment: a prospective observational study

Background: Postoperative pain assessment relies primarily on numeric self-report tools, such as the numerical rating scale (NRS); these tools require abstract numerical cognition and may be challenging for some patients in the immediate postoperative period. Thus, in this prospe...

Obstetric intensive care unit admissions and maternal near-miss: insights from a four-year cohort in Turkey

Abstract Background Severe maternal complications requiring intensive care unit (ICU) admission remain important indicators of maternal health, particularly in middle-income settings. This study aimed to evaluate the indications for intensive care unit (ICU) admission, maternal a...

Preoperative CRP–Albumin–Lymphocyte (CALLY) Index Is Associated with Survival but Does Not Predict Anastomotic Leak or Major Morbidity After Minimally Invasive Esophagectomy

Background/Objectives: The CRP–albumin–lymphocyte (CALLY) index is promoted both as a marker of postoperative morbidity and as a prognostic factor for survival. These claims are rarely tested together, thresholds usually come from the dataset in which they are then tested, and th...

Association of Complete Metabolic Response on Post-Neoadjuvant 18F-FDG PET/CT with Complete Cytoreduction in Advanced High-Grade Serous Tubo-Ovarian Carcinoma: A Retrospective Single-Center Cohort Study

Background/Objectives: To evaluate whether complete metabolic response (CMR) on 18F-FDG PET/CT after neoadjuvant chemotherapy (NACT) is associated with complete cytoreduction at interval debulking surgery (IDS), progression-free survival (PFS), and overall survival (OS) in patien...

Beyond corneal structure in Noonan syndrome: topographic, tomographic, and optical findings

Introduction This study aimed to evaluate corneal topographic, tomographic, and wavefront characteristics in individuals with Noonan syndrome (NS) and to compare these findings with those of healthy controls.Methods This prospective, case–control study included 18 patients with N...

Structural and Optical Corneal Alterations in Inactive Herpetic Keratitis: A Quantitative Tomographic Analysis

Purpose To quantitatively characterize the structural and optical changes in the cornea in inactive herpetic keratitis and, secondarily, to evaluate whether these parameters vary according to lesion location and depth of vascularization.Methods This prospective cross-sectional st...

Clinicopathological evaluation of crescentic glomerulonephritis: a retrospective single-center study

Abstract Aim Crescentic glomerulonephritis (GN) represents a group of diseases characterized by rapid and severe kidney damage within weeks or months. This study aimed to evaluate the demographic, laboratory, histopathological features, treatment approaches, and renal survival of...

The effect of pulmonary nodule presence on disease severity and course in ANCA-associated vasculitis: a multicenter cohort study

Pulmonary nodules are common in ANCA-associated vasculitis (AAV), but their clinical relevance remains unclear. This study assessed the influence of pulmonary nodules and radiological features on clinical characteristics and outcomes in AAV. In this multicenter retrospective coho...

Hematological changes in Cushing’s disease from diagnosis to remission: comparison with non-functioning pituitary adenomas

INTRODUCTION: Cushing's disease (CD) results in chronic hypercortisolism with multisystem complications. Although glucocorticoids affecthematopoiesis, sex-specific hematological alterations and their reversibility following treatment remain incompletely characterized.Most previou...