Islamic Azad University Medical Branch of Tehran

Perspective-taking in ICU nurses: a qualitative descriptive study

Abstract Background Perspective-taking is the cognitive and emotional process of understanding patients’ experiences from their viewpoint and is central to empathic, patient-centered care in intensive care units (ICUs). However, the ways ICU nurses draw on personal and profession...

Clinical outcomes of low versus high intensity laser therapy in patients with subacute carpal tunnel syndrome: A randomized, single-blinded, controlled trial

A common entrapment of median nerve that causes pain, numbness, and functional impairment is called Carpal Tunnel Syndrome (CTS). Laser therapy is a noninvasive intervention for neural repair and pain modulation, but comparative evidence between Low-Level Laser Therapy (LLLT) and...

Targeting ferroptosis in cancer: molecular mechanisms and emerging therapeutic strategies

Ferroptosis, an iron-dependent form of regulated cell death characterized by the lethal accumulation of lipid peroxides, has emerged as a pivotal pathway in cancer biology and a promising therapeutic target. This review synthesizes the core molecular machinery governing ferroptos...

Outcomes of endoscopic sinus surgery (ESS) on sino-orbital osteomas: ophthalmic manifestations and visual outcomes from a 12-year multicenter experience and literature review

Osteomas are the most common benign craniofacial bone tumors that may extend into the orbital cavity. While the majority of them remain asymptomatic, orbital involvement can lead to clinically significant ophthalmologic manifestations. Although endoscopic sinus surgery (ESS) has...

Chronic necrotizing aspergillosis after COVID-19: a case report

COVID-19-associated pulmonary aspergillosis (CAPA) has emerged as a concerning complication in critically ill patients. This report highlights a rare instance of chronic necrotizing aspergillosis (CNA) developing after COVID-19 in a patient with no classical risk factors. A 50-ye...

Barriers and facilitators of vector-borne diseases knowledge translation: a scoping review

Vector-borne diseases (VBDs) such as leishmaniasis, dengue, and malaria continue to pose major public health challenges, driven by environmental, socioeconomic, and climatic factors. Although numerous studies have generated valuable evidence, research findings are rarely translat...

Bifidobacterium longum prevent the progression of colon cancer via inhibiting metastasis and angiogenesis

Colorectal cancer (CRC) is one of the most common reasons for cancer-related death, and both angiogenesis and metastasis have established roles in CRC progression. Recent findings suggest that probiotics, like Bifidobacterium longum, are capable of suppressing anti-cancer activit...

Harnessing nanomedicine for breast cancer therapy through the immunomodulatory activity of BCc1

Although BCc1 represents a novel nanochelating-based nanomedicine, its route- and dose-dependent impacts on mammary oncogenesis, immunoregulation, and non-coding RNA (ncRNA) dynamics remain poorly defined. Here, female BALB/c mice bearing subcutaneous 4T1 mammary carcinomas were...

Intratumor microbiota in thyroid cancer: emerging insights into tumorigenesis and therapeutic potential

Thyroid cancer incidence has risen sharply in recent decades, yet the mechanisms underlying tumor development and progression remain incompletely understood. Recent evidence reveals that tumors, including thyroid malignancies, harbor distinct microbial communities, termed intratu...

Altered expression of ZAP70 and lnc-FAHD2B-3 in colorectal polyps: an exploratory molecular study

Colorectal cancer (CRC) is a major global health concern that often develops from precursor lesions, particularly adenomatous colorectal polyps. However, the molecular alterations associated with early colorectal neoplasia remain incompletely understood. ZAP70, a signaling molecu...

Cross-cultural adaptation and validation of the Persian version of the International Hip Outcome Tool-12 (iHOT-12-Pr) in young to middle-aged active adults with hip disorders

To our knowledge, no validated Persian version of the 12-item International Hip Outcome Tool (iHOT-12) has been published for assessing active adults with hip disorders. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the Persian iHOT-...

Extensive head and neck necrotizing fasciitis induced by mandibular canine tooth infection in an uncontrolled diabetic patient: a case report

Abstract Background Head and neck necrotizing fasciitis is a rare, progressive soft tissue infection that usually originates from odontogenic sources. Systemic diseases, including immunosuppression and diabetes mellitus, can complicate patient management. Case presentation We rep...

Intermittent fasting in diabetic retinopathy: microbiome modulation, mechanisms, and clinical insights.

Intermittent fasting, a nonpharmacological approach, shows promise for controlling diabetic retinopathy but lacks concrete human evidence directly associating intermittent fasting with eye responses. This review highlights preclinical research insights about intermittent fasting...

Quantitative Susceptibility Mapping‐Based Characterization of Lesion Heterogeneity in Multiple Sclerosis

ABSTRACT Background Quantitative susceptibility mapping (QSM) characterizes multiple sclerosis (MS) lesions through susceptibility changes related to iron and myelin. However, the prevalence, regional distribution, and relationship of QSM‐defined lesion subtypes with choroid plex...

Analysis of the Interactive Relationships Between Barriers Affecting Patients’ Informed Consent

Introduction Getting informed consent right isn’t just a box to check. It’s a vital part of building trust and ensuring the best possible care. When done well, it can make patients feel more confident and involved in their treatment, which often leads to better outcomes and highe...

Circular RNAs as regulators of epithelial‑mesenchymal transition in gliomas from molecular mechanisms to clinical applications

Epithelial–mesenchymal transition (EMT) is a fundamental biological process that drives glioma invasion, therapeutic resistance, and malignant progression. Recent evidence highlights circular RNAs (circRNAs) as pivotal post-transcriptional regulators that orchestrate EMT through...

Analytical determination of contamination depth of 137 Cs point sources in reactor building walls

Abstract The presence of radioactive contamination in concrete structures poses a silent yet serious threat to both environmental safety and public health. Such contamination, if not properly localized, can lead to prolonged radiation exposure, difficulties in decommissioning, an...

Plasma p-tau217 as a two-cutoff approach to improve tau-PET screening and trial recruitment in Alzheimer’s disease

Abstract Blood-based biomarkers could broaden access to Alzheimer’s disease diagnostics, but their ability to approximate tau PET, and to address gray-zone results, remains uncertain. We evaluated plasma p-tau217 against tau PET using a harmonized ADNI baseline cohort and an inde...