Isfahan University of Technology

SynCellNet: generative AI framework for single-cell RNA sequencing data generation and validation

Generative AI plays a pivotal role in addressing the challenges of data scarcity and class imbalance in single-cell transcriptomics. In this work, we present SynCellNet, a generative AI technique for synthesis of single-cell gene expression profiles. SynCellNet can be used to enr...

Plasma p-tau217 as a two-cutoff approach to improve tau-PET screening and trial recruitment in Alzheimer’s disease

Abstract Blood-based biomarkers could broaden access to Alzheimer’s disease diagnostics, but their ability to approximate tau PET, and to address gray-zone results, remains uncertain. We evaluated plasma p-tau217 against tau PET using a harmonized ADNI baseline cohort and an inde...