IRCCS Policlinico San Donato

Salivary Dim‐Light Melatonin Onset is Associated with Functional Decline, Respiratory Symptom Emergence, and Survival in Early Amyotrophic Lateral Sclerosis

OBJECTIVE: Sleep-wake and circadian disturbances are increasingly recognized in people living with amyotrophic lateral sclerosis (plwALS), but endogenous circadian phase timing and its prognostic significance in early disease remain unclear. We assessed whether salivary dim-light...

Impaired Flow and Physiology in Coronaries With Anomalous Origin From the Opposite Sinus of Valsalva

BACKGROUND: Anomalous Aortic Origin of a Coronary Artery (AAOCA) high-risk anatomical features (intramural segment, acute take-off angle, slit-like ostium) cause coronary stenosis leading to myocardial infarction. How these features alter coronary physiology remains unclear. AIMS...

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

A consortium-driven framework for biomarker prioritization in the HEBE aging study

Abstract Aging is a complex biological process influenced by chronic low-grade inflammation, oxidative stress, and metabolic dysregulation, collectively termed inflammaging. The HEBE (Healthy aging versus inflamm-aging: the role of physical Exercise in modulating the Biomarkers o...

Regional biomechanical differences in human ascending aortic aneurysm wall: a paired anterior–posterior analysis

Regional heterogeneity of ascending aortic wall is thought to play a key role in the development of aortic aneurysms. Along the circumference of the vessel, anterior and posterior regions exhibit distinct characteristics. However, intra-patient comparative mechanical data between...

Self-care–based clinical and metabolic profiles among adults with type 2 diabetes: a cross-sectional cluster analysis

Type 2 diabetes mellitus is a heterogeneous condition influenced by clinical, metabolic, and behavioral factors. Traditional approaches to diabetes management often rely on single clinical indicators and may overlook meaningful patterns in patients’ self-care behaviors. This stud...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...

Buddy Wire–Augmented Intravascular Lithotripsy in Refractory Calcified Coronary Lesions: A Five‐Case Series

Heavily calcified coronary lesions remain a major challenge in percutaneous coronary intervention (PCI), often limiting the effectiveness of intravascular lithotripsy (IVL). We report a five-case series in which IVL failed to achieve adequate lesion modification but was successfu...

A Modified Delphi consensus on early management of combined cardiovascular risk factors in adult patients with type 2 diabetes in Italy

BACKGROUND: Type 2 diabetes (T2D) is a complex chronic disease often associated with other metabolic conditions that increase the risk of cardiovascular (CV) disease and early mortality. Hence, early, integrated management of T2D may prevent long-term CV complications. METHODS: T...

Comparisons of Novel Risk Stratification Models to the Current cT1a/b Staging in Incidental Prostate Cancer

OBJECTIVE: Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (< 5% vs. > 5%) in the resected tissue. We tested for other models that could improve cancer-specific survival (CSS) predictions. METHODS: Incide...