IRCCS Ospedale San Raffaele

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Performance evaluation of a preclinical SPECT system and optimization of imaging protocols for 177Lu-labelled radiopharmaceuticals

This study investigates the performance of the γ-CUBE preclinical SPECT scanner to optimize acquisition and reconstruction protocols for theranostic preclinical studies, and to determine the minimum administered activity of a novel 177 Lu-labelled peptide in a mouse cancer model...

Growth factor polygenic disposition shapes associations of childhood adversity with gray matter and clinical profiles in depression: A two‐cohort imaging‐genetics study

Aim Adverse childhood experiences (ACE) are associated with greater symptom severity and treatment resistance in major depressive disorder (MDD), but their effects vary markedly across individuals. Growth factor polygenic profiles may contribute to this differential susceptibilit...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Serum NfL predicts visual recovery and neuronal loss after optic neuritis

Optic neuritis, a common manifestation of multiple sclerosis, involves acute axonal injury and variable visual recovery. We evaluated whether serum neurofilament light chain predicts visual and structural outcomes after first-episode optic neuritis. Fifty-one patients (mean age =...

Comparative Effectiveness of Tocilizumab and Tumor Necrosis Factor Inhibitors in Takayasu Arteritis: Age‐Related Differences in Treatment Response

OBJECTIVE: Comparative, prospective data on biologics for Takayasu arteritis (TAK) are limited. We compared tumor necrosis factor inhibitors (TNFi) and tocilizumab (TCZ) in a combined cohort, assessed demographic and cytokine influences, and evaluated longitudinal outcomes. METHO...

CD146 + cell engraftment improves vascularization, and impact tissue remodelling in dystrophic skeletal muscle of mdx mice

CD146 + cells have been described as myogenic progenitors residing in the interstitial space of skeletal muscle in both mice and humans. Previous studies demonstrated that intramuscular transplantation of CD146 + cells can enhance regeneration of injured or immobilized skeletal m...

The gut microbiome in multiple myeloma: from disease evolution to therapeutic modulation

The therapeutic landscape of Multiple Myeloma (MM), the second most common haematological malignancy, has undergone a paradigm shift with the introduction of anti-CD38 targeting monoclonal antibodies, immunomodulatory drugs and B-cell maturation antigen (BCMA) targeting Chimeric...

Clinical Management of Myocardial Infarction

Despite notable advancements in the acute and long-term management, coronary artery disease and myocardial infarction (MI) remain the leading cause of mortality worldwide. Atherothrombosis overlying coronary plaque rupture or erosion is the main pathophysiological mechanism of MI...

Telerehabilitation for Motor Recovery in Adults with Neurological Disorders: A Systematic Review and Meta-Analysis Across Motor Domains, Delivery Models, and Follow-Up Effects

Background/Objectives: Telerehabilitation may extend neurorehabilitation beyond conventional settings, but comparative effects across neurological diagnoses and motor domains remain uncertain. This systematic review and meta-analysis synthesized motor outcomes while distinguishin...

Circuits that guarantee iron homeostasis: from cellular sensing to systemic control

Abstract Iron is an essential yet potentially toxic element whose redox properties support diverse cellular processes, including oxygen transport, energy metabolism, DNA synthesis, and epigenetic regulation. To maintain iron availability while limiting its toxicity, organisms hav...

Association Between Proton Pump Inhibitor Use and Gastric Neuroendocrine Neoplasms in Autoimmune Gastritis: A Real‐World Propensity Score‐Matched Study From the Autoimmune gastRitis Italian netwOrk Study grOup

ABSTRACT Background and Aims Autoimmune gastritis (AIG) is characterized by chronic hypergastrinemia and is associated with an increased risk of gastric neuroendocrine neoplasms (gNENs). Because proton pump inhibitors (PPIs) further increase gastrin secretion, concerns have been...

Deep Learning for Quantitative Perfusion 99mTc-ECD SPECT in Clinically Confirmed Neuropsychiatric Systemic Lupus Erythematosus: Comparison with Established Software

Abstract Purpose We compared a novel deep learning (DL)-based quantification software (BTXBrain) with an established platform (Q.Brain) for quantitative perfusion single photon emission computed tomography (SPECT) in patients with clinically confirmed neuropsychiatric systemic lu...

Types of Self-Expandable Metal Stents for Palliative Drainage of Unresectable Extrahepatic Malignant Biliary Obstruction: A Network Meta-Analysis of Randomized Controlled Trials

Background: The optimal self-expandable metallic stent (SEMS) choice for endoscopic drainage of unresectable extrahepatic malignant biliary obstruction (MBO) with endoscopic retrograde cholangiopancreatography (ERCP) remains unclear due to limited randomized controlled trial (RCT...

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

OA03-RF01.06. Topographical Classification of Postesophagectomy Anastomotic Leakage Based on CT Findings

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Anastomotic leakage is a severe complication after esophagectomy. Postoperative imaging is essential for detecting it, with CT scans using both intravenous and...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...