IRCCS Materno Infantile Burlo Garofolo

Childhood-onset Sjögren disease : clinical phenotype compared with adult-onset disease, disease course and treatment patterns in a nationwide Italian multicentre pediatric cohort

Childhood-onset Sjögren disease (cSjD) is a rare autoimmune disease with an incompletely characterized phenotype, limited longitudinal data, no validated classification criteria, and limited evidence to guide treatment. To compare the clinical and serological phenotype of childho...

A Novel Application of the Volumetric Absorptive Micro Sampling Strategy to Quantify Dexmedetomidine in Capillary Blood Using an LC – MS / MS Method

BACKGROUND: Pain control in neonates is crucial as inadequate management may impair neuronal development. Dexmedetomidine (DEX), an alpha2 agonist, is approved for intravenous use in ventilated neonates. While intranasal DEX is off-label in neonates and children, studies show its...

Spatially Grounded Neurosymbolic AI for Explainable Retinal Disease Classification From OCT Images

Purpose: To develop and evaluate a spatially grounded neurosymbolic AI framework for explainable multilabel retinal disease classification from optical coherence tomography (OCT) images, integrating convolutional neural network (CNN)–based retinal sign extraction, symbolic clinic...

Identifying implementation research priorities for the ENAP (Every Newborn Action Plan) and EPMM (Ending Preventable Maternal Mortality) networks: mixed-methods study in six Asian countries

Abstract Background The ENAP and EPMM, now unified as Every Woman Every Newborn Everywhere (ENEW), are multi-partner and multi-country networks to end preventable maternal, neonatal mortality, morbidity, and stillbirth, primarily led by United Nations agencies. Several authors pr...

Physical Activity, Screen Time, and Neurobehavioural Function at Age 7 Years: The Italian PHIME-NAC-II Cohort

Objective: To investigate the cross-sectional associations of physical activity (PA) and interactive and passive screen-time (ST) exposure with behavioural and cognitive development at age 7 years within the PHIME-NAC-II prospective birth cohort. Methods: At age 7 years, 482 chil...

Neurosymbolic approach improves robustness of deep learning models for semantic segmentation of MII human oocyte images

Morphology-based assessment of metaphase II (MII) oocytes remains an important component of intracytoplasmic sperm injection (ICSI) workflows, but it is affected by inter-operator variability and limited reproducibility. Deep learning approaches have shown promise for automated s...

Community-based monitoring of neonatal jaundice using the point-of-care Bilistick® System 2.0

Neonatal jaundice often peaks after discharge, creating the need for reliable post-discharge monitoring. This study evaluated the feasibility and safety of a hospital-to-community pathway using the Bilistick® System 2.0 within routine Community Health Family Services (CHFS). This...

The anti-GPC1 antibody AT101 as effective targeting agent for chemotherapeutic-loaded chitosan nanobubbles in the treatment of pancreatic adenocarcinoma

Recently, we developed AT101, an IgM-class mouse monoclonal antibody directed against glypican-1 (GPC1), a proteoglycan considered as useful target for pancreatic adenocarcinoma (PDAC) treatment being specifically and highly expressed on PDAC cell surface. Here, we proposed AT101...

Salivary hormones and adipokines are associated with glycemic control and early renal and cardiometabolic markers in children and young adults with type 1 diabetes

Abstract Purpose Type 1 diabetes (T1D) is recognized as a complex metabolic condition associated with hormonal dysregulation and early complications. This study aimed to evaluate salivary metabolic hormones and adipokines in children and young adults with T1D, and to assess their...

The burden of male breast cancer (MBC) in the GBD Central, Eastern, and Western Europe Regions from 1990 to 2023: Results from the Global Burden of Disease Study 2023

PURPOSE: Male breast cancer (MBC) is underrepresented in cancer statistics: this study aimed to assess the burden of MBC in Central, Eastern, and Western Europe from 1990 to 2023, using data from the Global Burden of Disease (GBD) Study 2023. METHODS: Estimates from GBD 2023 were...