IRCCS Eugenio Medea

Large-Scale Cerebellar-Cerebral Network Alterations Underlying Impaired Social Predictive Processing in Cerebellar Neurodegeneration

Abstract The cerebellum is a key node for detecting and adjusting social-prediction internal models. Yet social prediction has been scantly investigated in neurodegenerative cerebellar patients (CB). Thus, we examined CB social-prediction abilities and related cerebellar-cerebral...

Real-world adjunctive use of an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes in drug-resistant epilepsy: the multicentre retrospective ARMILLA study

The purpose of this study was to describe real-world adjunctive use, tolerability, and hypothesis-generating seizure and multidomain outcomes of LALBAAY, an alpha-lactalbumin/sodium butyrate Food for Special Medical Purposes (FSMP), in patients with drug-resistant epilepsy (DRE)....

RNAmotifs 2.0: a framework for inferring multivalent RNA motifs and their candidate regulators of splicing

Alternative splicing expands proteomic diversity and is shaped by RNA‑binding proteins (RBPs) that bind to multivalent RNA motifs. Yet connecting cis-acting motifs to their candidate trans-acting protein remains difficult from sequence information alone. Here we present RNAmotifs...

Large-scale electrophysiological signatures of Williams syndrome: evidence from oscillatory power and brain fluidity

Evidence suggests that Williams syndrome (WS) may be associated with atypical cortical oscillatory activity and large-scale structural and functional anomalies. However, links between whole-brain electrophysiological measures and cognitive performance in WS remain scarce. This st...

Multilevel narrative assessment in children with early cochlear implants compared to typically hearing peers

Cochlear implants (CIs) provide auditory access that supports the development of oral language in deaf children with severe-to-profound hearing loss, especially when implantation occurs early. This study assessed narrative abilities in 16 school-aged children with early CIs compa...

Multimodal pragmatic assessment in healthy aging: The interplay with Executive Functioning, Theory of Mind and Cognitive Reserve

Pragmatic competence is crucial for effective social interaction and well-being, and yet it tends to decline with age. While most research has focused on basic linguistic skills, the multimodal nature of communication and the cognitive processes that support it have often been ov...