IP Australia

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

Synergistic Orchestration of Chlorogenic Acid Analogs in Sugarcane Molasses Polyphenols for Sucrase Inhibition: Insights into a Multilevel Inhibitory Mechanism

This study systematically explored the inhibitory mechanisms against sucrase exerted by sugarcane molasses polyphenol extract (SMPE) and its three principal chlorogenic acid analogs: neochlorogenic acid (NA), chlorogenic acid (CA), and methyl chlorogenate (MC). By integrating in...

Jaundice and Mycoplasma ovis in Australian sheep

Mycoplasma ovis has been known to infect Australian sheep for >60 years. The infection can induce haemolytic anaemia with associated ill-thrift and occasionally mortality. The haemolysis can also lead to jaundice in subclinically infected sheep sent for slaughter. Jaundiced lamb...

Predictive validity of the Addenbrooke’s cognitive Examination III for on-road driving outcomes in a clinical fitness-to-drive population: a prospective cohort study

Background Evidence-based fitness-to-drive assessment must balance public safety and fairness. Cognitive screens are commonly used, but must be accurate in high-stakes contexts. The predictive utility of the Addenbrooke’s Cognitive Examination III (ACE-III) for driving outcomes r...