Institution
Ionis Pharmaceuticals (United States)
Recent research
- Health & Medicine
Hyperglycemia Drives an Activated, Lipid-Laden Nonclassical Monocyte Phenotype in Diabetes
The presence of lipid-loaded macrophages in the artery wall and kidney characterizes diabetic atherosclerotic cardiovascular disease and diabetic kidney disease, respectively. Monocytes, the bone marrow–derived precursors of macrophages, accumulate lipids in response to hyperchol...
- Biology
Automated Multimodal Correlative Registration for Organelle-Specific Elemental and Isotopic Imaging
Abstract Mapping the subcellular partitioning of therapeutics is important for understanding their trafficking, mechanisms of action, and off-target effects. NanoSIMS provides chemical images of labeled therapeutics, but assigning these signals to cellular structures requires cor...
- BiologyOpen access
Characterization of Regioisomeric Conjugates Arising from Pixantrone at AP Sites in DNA
Abstract Alkylation at N7 of guanine leads to formation of abasic (AP) sites in DNA. These equilibrate between α and β anomers and form conjugates with 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione (Pixantrone, PIX). NMR revealed that these conjugates formed as regi...
- Health & MedicineOpen access
Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...
- BiologyOpen access
The (pro)renin receptor [(P)RR] plays a crucial role in murine kidney development, but its function in human kidneys remains poorly understood due to the lack of suitable research models. Human induced pluripotent stem cell (iPSC)-derived kidney organoids recapitulate early kidne...