Io Therapeutics (United States)

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...

Parturition attenuates endothelial senescence to resist nitrosative stress-induced heart failure with preserved ejection fraction in mice

Abstract Background Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of heart failure patients and is biased toward elderly females. Nitrosative stress-induced HFpEF animal studies fail to phenocopy this sex bias and the underlying pathological mechanisms r...

Overcoming immune checkpoint inhibitor-mediated T-cell exhaustion with a TCR β chain-directed selective dual T-cell activator

Abstract Background Resistance to immune checkpoint inhibition (ICI) using antibodies against the PD-1/PD-L1 axis remains a significant clinical challenge. Here, we report that combination of anti-PD-1 with a bifunctional fusion molecule, anti-TCRβ-IL-2, comprised of a monovalent...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Unlocking Scalable Ligand Residence Time Predictions with Koffee Unbinding Kinetics Simulations

A great number of drug discovery programs fail due to poor in vivo efficacy and ADMET liabilities. On- and off-target ligand residence times can act as important drivers of these problems. While modern experimental techniques have made measuring compound kinetics data more routin...

Heterologous Expression of Thanatin Using Dual Transposon System in Saccharomyces cerevisiae

Thanatin is a small cationic antimicrobial peptide with broad-spectrum antibacterial activity, considered a promising candidate to combat the global antibiotic resistance crisis. Microbial biosynthesis represents an attractive strategy for sustainable production of antimicrobial...