International Institute of Molecular and Cell Biology

Domain-Aware Feature Engineering for Prediction of Molecular Optical Interference in High-Throughput Screening

Abstract Optical interference from small molecules─compounds that absorb UV/visible light or exhibit intrinsic fluorescence─is a significant source of false positives and false negatives in fluorescence- and absorbance-based high-throughput screening assays. Computational predict...

Mammalian DNA maintenance methylation depends on histone but not PAF15 ubiquitination

In mammals, DNA methylation is an essential inheritable epigenetic modification maintained by the DNMT1-UHRF1 machinery in a UHRF1 E3 ubiquitin ligase-activity-dependent manner. UHRF1-catalyzed histone ubiquitination and PAF15 ubiquitination have been proposed to recruit DNMT1 to...