International Collaboration On Repair Discoveries

Granzymes in Neuroinflammation and Neurodegenerative Diseases

Abstract Neuroinflammation is a central driver of numerous neurological disorders. While granzymes have classically been studied as cytotoxic effector molecules secreted from immune cells along with the pore-forming molecule, perforin, accumulating evidence suggests that these se...

Filtering spinal cord stimulation artifacts while preserving muscle activity during exoskeleton assisted walking after spinal cord injury

Analyzing surface electromyography in the presence of transcutaneous spinal cord stimulation requires the filtering of electrical stimulation artifacts. Limitations of previous filtering approaches include the use of a uniform filter and excessive removal of muscle activity of in...

Awake craniotomy for drug-resistant non-oncological epilepsy: a systematic review of feasibility, reported safety, and seizure outcomes

Abstract Introduction Complete resection of the epileptogenic zone offers the best chance of seizure control in patients with drug-resistant epilepsy. However, surgical management remains challenging when the epileptogenic zone is located within or adjacent to eloquent brain regi...

Protocol for induction and quantification of injury-primed axon outgrowth in adult mouse DRG neurons

Adult dorsal root ganglion (DRG) neurons provide a powerful model to study axon growth. Dissociated lumbar L3-L5 DRG neurons extend axons de novo in culture, enabling the measurement of baseline outgrowth. Here, we present a protocol for inducing and quantifying injury-primed axo...