International Clinical Research Center, St. Anne's University Hospital Brno

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Optimal Depolarization Sequence for CRT Patients

Abstract Background Electrical ventricular dyssynchrony is a hallmark of intraventricular conduction disease in heart failure with reduced ejection fraction. Although cardiac resynchronization therapy (CRT) is effective, a proportion of patients with ECG evidenced electrical dyss...