Intermountain Healthcare

Effect of Vasopressin Initiation Threshold on Septic Shock Mortality

Importance The optimal vasopressor dose at which to initiate a second vasopressor in patients with septic shock is uncertain. Objective To compare the effects of hospital-level strategies initiating vasopressin infusion at a lower threshold vs a higher threshold on outcomes in pa...

Use of Anticoagulation Among Patients With Atrial Fibrillation or Atrial Flutter in the United States

BACKGROUND: Oral anticoagulation (OAC) remains underused in patients with atrial fibrillation or flutter at high risk of ischemic stroke. We aimed to characterize documented OAC prescribing at diagnosis and during 1-year follow-up and identify factors associated with baseline OAC...

A Systematic Replication: Instructive Feedback to Produce Emerging Play Responses

Abstract Social deficits are common in children diagnosed with autism spectrum disorder (ASD). To help facilitate the development of social behaviors, practitioners may target specific play skills, such as with toys. Previous researchers have used discrete trial training (DTT) to...

Inpatient Deaths in Pediatric Leukodystrophies

ABSTRACT Background and Objectives Leukodystrophies are neurogenetic diseases affecting the white matter of the central nervous system. The contributing factors for leukodystrophy mortality are incompletely understood. Our objectives were to characterize inpatient deaths of pedia...

Postoperative inflammatory markers and surgical wound infection after elective short-segment lumbar fusion: the importance of surgical context

Abstract. Introduction: Postoperative white blood cell (WBC) count and neutrophil-to-lymphocyte ratio (NLR) are routinely available after lumbar fusion, but early elevations may reflect surgical stress. We evaluated associations of postoperative day (POD) 1 and POD3 WBC/NLR with...

Plain Radiograph Use in Pediatric Blunt Trauma Patients with Suspicion for Cervical Spine Injury: A Prospective Observational Analysis of the Western Pediatric Cervical Spine Study

BACKGROUND: Despite guideline support for plain radiography (XR) in low-risk pediatric blunt trauma, CT remains the predominant imaging modality for cervical spine evaluation, increasing radiation exposure. We evaluated contemporary XR utilization and its diagnostic performance i...

Effectiveness of RSV Prevention Strategies in US Infants: 2024–2025

OBJECTIVE: In 2023, 2 products, a long-acting monoclonal antibody (nirsevimab) and maternal respiratory syncytial virus (RSV) vaccination, were recommended in the United States to prevent severe RSV disease among infants in their first RSV season. Low uptake during the 2023 to 20...